Ethanol Extracts of Fresh Davallia formosana (WL1101) Inhibit Osteoclast Differentiation by Suppressing RANKL-Induced Nuclear Factor-κB Activation

Figure 6

WL1101 inhibits ovariectomy-induced trabecular bone loss in isolated tibia on Day 33. Distilled water or WL1101 (50 or 200 mg/kg/day) was orally administered to OVX rats via gastric intubation for 33 days (once/day). The rats were sacrificed on Day 33, and tibiae and femora were collected. Isolated tibiae were analyzed by μCT. It was shown that administration of WL1101 antagonized OVX-induced decrease of trabecular BMD (a), bone volume (b), bone surface (c), and bone number (d). WL1101 exerted less effects on OVX-induced changes of trabecular bone thickness (e) and structure model index (SMI) (f). Each value represents mean ± S.E.M (𝑛=8--11). ^∗𝑃<0.05 compared with sham-operated group. ^#𝑃<0.05 compared with the OVX-control group.

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