A Metabolomics Profiling Study in Hand-Foot-and-Mouth Disease and Modulated Pathways of Clinical Intervention Using Liquid Chromatography/Quadrupole Time-of-Flight Mass Spectrometry
Top five significant molecular networks of HFMD related metabolites merged by IPA. Metabolites are represented as nodes, and the biological relationship between two nodes is represented as a line. Note that the colored symbols represent metabolites that occur in our data, while the transparent entries are molecules from the Ingenuity Knowledge Database. Red symbols represent upregulated metabolites in HFMD patients; green symbols represent downregulated metabolites in HFMD patients. Solid lines between molecules indicate direct physical relationship between molecules; dotted lines indicate indirect functional relationships.