Antitussive Activity of the Water-Extracted Carbohydrate Polymer from Terminalia chebula on Citric Acid-Induced Cough

Figure 3

The influence of the carbohydrate polymer (CP) from T. chebula, codeine (positive control) and water for injection (negative control), on the citric acid-induced cough efforts in guinea pigs recorded at 30, 60, 120, and 300 min time intervals. The number of cough efforts before the application of the polysaccharides and codeine is given by N. 𝑃<0.05 was considered statistically significant, and the significance of 𝑃<0.05; 𝑃<0.01; and 𝑃<0.001 is shown by *, **, or ***, respectively. All used substances were applied by peroral route of administration: plant polysaccharides in the dose of 50 mg kg⁻¹, codeine in the dose 10 mg kg⁻¹ and water in the dose 1 mL kg⁻¹, body weight.