Evidence-Based Complementary and Alternative Medicine / 2013 / Article / Fig 7

Research Article

Icariin Augments Bone Formation and Reverses the Phenotypes of Osteoprotegerin-Deficient Mice through the Activation of Wnt/β-Catenin-BMP Signaling

Figure 7

Icariin-induced osteoblast differentiation in a β-catenin-dependent manner. Ad-Cre infection significantly inhibited Icariin-induced expression of BMP2 (a), BMP4 (b), ALP (c), and OC (d). Ad-Cre-mediated deletion of the β-catenin gene was demonstrated by the reduction of β-catenin mRNA (e) and protein (f) expression in these cells. Data were expressed as mean ± SD, . , unpaired Student’s t-test (Ad-GFP + Icariin group versus Ad-GFP + Control group) and , unpaired Student’s t-test (Ad-Cre + Icariin group versus Ad-GFP + Icariin group).
652317.fig.007a
(a)
652317.fig.007b
(b)
652317.fig.007c
(c)
652317.fig.007d
(d)
652317.fig.007e
(e)
652317.fig.007f
(f)

Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.