A Review on Antihyperglycemic and Antihepatoprotective Activity of Eco-Friendly Punica granatum Peel Waste

Table 6

Overview of in vivo Punica peel studies for diabetes and its complications.

Preclinical; trial	in vivo studies	Day/week	Nature of peel extract/dosages; (per kg BW/day)	Outcome	Statistically significant results?	Reference
Diabetes	Albino Wistar rats	28/4	Aqueous/0.42 g	Lowering of blood sugar level and increased number of 𝛽 cells	Yes	[47]
Diabetes	Albino Wistar rats	10/1.3	Methanolic/200 mg	Increase of the activities of antioxidant enzymes catalase, superoxide dismutase, glutathione peroxidase, glutathione-S-transferase, and glutathione reductase, in liver and kidney	Yes	[48]
Diabetes	Albino Wistar rats	15/2.3	Methanolic/200 mg	Improvement of hepatic, cardiac, and renal LPO and serum T3, T4, insulin, and glucose concentrations	Yes	[49]
Hyperlipidemic	Sprague-Dawley rats	28/7	Methanolic/5%, 10%, 15%	Reduction of total cholesterol, LDL-cholesterol, triglycerides. VLDL-cholesterol H	Yes	[50]
Diabetes	Albino Wistar rats	28/7	Methanolic/10 mg, 20 mg	Increase of the activities of antioxidant enzymes catalase, superoxide dismutase, glutathione peroxidase, glutathione-S-transferase, and glutathione reductase, in liver and kidney	Yes	[50]
Diabetes	Albino Wistar rats	42/6	Methanolic/75 mg and 150 mg	Increase of the activities of antioxidant enzymes catalase, superoxide dismutase, glutathione peroxidase, and decreased LPO level in hippocampal and cortex region of brain	Yes	[8]
Diabetes	Albino Wistar rats	21/3	Methanolic/200 mg and 400 mg	Reduction of aldose reductase, amylase, PTP1B inhibition assay	Yes	[32]