A Computational Drug-Target Network for Yuanhu Zhitong Prescription

Table 2

The eHiTS scores of potential targets.

NO	Gene name	PDB	Protein name	Compounds	eHiTS score
1	ESR1	1R5K	Estrogen receptor	corydaline	−6.99
2	DRD3	3PBL	D(3) dopamine receptor	corydaline	−6.53
3	CHRM2	3UON	Muscarinic acetylcholine receptor M2	corydaline	−6.33
4	CHRM3	4DAJ	Muscarinic acetylcholine receptor M3	corydaline	−6.28
5	CRYZ	1YB5	Quinone oxidoreductase	oxypeucedanin	−5.59
6	TOP2A	1ZXN	DNA topoisomerase 2-alpha	oxypeucedanin_M1	−5.79
7	VKORC1	3KP9	Vitamin K epoxide reductase complex subunit 1	byakangelicin	−6.04
8	ESR2	1QKM	Estrogen receptor beta	α-Allocryptopine	−6.13
9	ACE	1UZF	Angiotensin-converting enzyme	tetrahydroberberine	−5.69
10	ADRA1A	3SN6	Alpha-1A adrenergic receptor	tetrahydropalmatine	−5.97
11	OPRK1	4DJH	Kappa-type opioid receptor	tetrahydropalmatine	−5.57
12	HRH1	3RZE	Histamine H1 receptor	tetrahydropalmatine	−5.52
13	ADRA2A	3RFM	Alpha-2A adrenergic receptor	Tetrahydropalmatine_M2	−6.90
14	ABCC8	2BBO	ATP-binding cassette transporter subfamily C member 8	protopine_M1	−5.52
15	KCNJ8	3HFC	ATP-sensitive inward rectifier potassium channel 8	protopine_M1	−5.74
16	BCHE	2WIL	Cholinesterase	protopine_M1	−5.42
17	RNASE3	1DYT	Eosinophil cationic protein	protopine_M1	−5.21