Acetonic and Methanolic Extracts of Heterotheca inuloides, and Quercetin, Decrease CCl₄-Oxidative Stress in Several Rat Tissues

Table 1

Effect of extracts of H. inuloides and quercetin, on serum clinical chemistry parameters of Wistar rats untreated and CCl₄ treated at dose of 1.5 mL/kg for three consecutive days.

Group	ALP	𝛾-GLOB	ALB	BB	CRE	CK
O.O	216.6 ± 7	7.0 ± 1.0	1.18 ± 0.15	1.30 ± 0.20	0.40 ± 0.02	100.00 ± 13
P.B	215.3 ± 12	6.0 ± 1.3	1.10 ± 0.05	1.40 ± 0.10	0.42 ± 0.03	110.54 ± 15
Ac.E	183.0 ± 8	4.8 ± 0.59	1.16 ± 0.15	1.90 ± 0.20	0.49 ± 0.04	171.05 ± 12
Me.E	204.3 ± 31	5.25 ± 1.0	1.03 ± 0.05	1.70 ± 0.10	0.47 ± 0.02	157.47 ± 10
Quer	159.0 ± 14	4.49 ± 0.54	1.05 ± 0.07	1.60 ± 0.10	0.45 ± 0.03	105.62 ± 9
CCl4	271.6 ± 7^α,+	1.5 ± 0.30*	0.65 ± 0.05*	3.8 ± 0.10*	0.90 ± 0.04*	321.25 ± 15*
Ac.E + CCl4	234.0 ± 6	5.50 ± 0.57	0.96 ± 0.05	2.0 ± 0.10	0.47 ± 0.03	212.48 ± 15
Me.E + CCl4	227.3 ± 5	5.66 ± 0.47	0.99 ± 0.02	1.50 ± 0.10	0.45 ± 0.01	197.87 ± 13
Quer + CCl4	121.5 ± 22	5.2 ± 0.15	1.05 ± 0.07	1.10 ± 0.10	0.44 ± 0.02	149.73 ± 19

Alkaline phosphatase (ALP) (U/L), 𝛾-globulin (𝛾-GLOB) (g/dL), serum albumin (ALB) (g/dL), total bilirubin (BB) (𝜇mol/L), creatinine (CRE) (𝜇mol/L), creatine kinase (CK) (U/L). *𝑃<0.01 versus all groups; ^α𝑃<0.01 versus O.O, P.B, Ac.E, Me.E, Quer, Ac.E + CCl₄, Quer + CCl₄; ⁺𝑃<0.05 versus Me.E + CCl₄. Each determination was performed twice, in triplicate, and the values represent the mean ± SD. 𝑛=3.