Interaction of Acupuncture and Electroacupuncture on the Pharmacokinetics of Aspirin and the Effect of Brain Blood Flow in Rats

Table 1

The pharmacokinetic parameters of aspirin and salicylic acid for the rat blood. The control group (aspirin administration 30 mg/kg only); the acupuncture group (acupuncture stimulation 15 min before aspirin administration 30 mg/kg); the electro-acupuncture group (electro-acupuncture stimulation 15 min before aspirin administration 30 mg/kg).

Parameter	Aspirin (30 mg/kg)	Aspirin (30 mg/kg) + acupuncture	Aspirin (30 mg/kg) + electro-acupuncture
Aspirin
𝑡1/2 (min)	12±2	11±2	12±4
AUC (min 𝜇g/mL)	113±33	95±10	92±5
Cl (mL/min/kg)	291.8±62.4	333.0±70.5	343.0±50.1
Vd (mL/kg)	3.6±0.8	3.8±1.9	3.9±0.5
Salicylic acid
𝑡1/2 (min)	289±46	215±22	225±15
AUC (min 𝜇g/mL)	2854±518	2565±322	2304±220
Cl (mL/min/kg)	8.6±2.6	9.3±1.1	10.4±1.5
Vd (mL/kg)	3.3±1.0	2.5±0.6	2.65±0.1

Data expressed as mean ± S.E.M. (𝑛=6). 𝑡_1/2: elimination half-life, AUC: area under the concentration-time curve, Cl: clearance, Vd: apparent volume of distribution.