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Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 672873, 12 pages
http://dx.doi.org/10.1155/2013/672873
Review Article

Hyperthermia versus Oncothermia: Cellular Effects in Complementary Cancer Therapy

1Department of Complementary and Alternative Medicine, University of Pécs, Hungary
2Department of Physiology, University of Debrecen, and Institute of Human Physiology and Clinical Experimental Research, Semmelweis University, Hungary
3Department of Biotechnics, St. Istvan University, Gödöllő, Hungary

Received 7 October 2012; Accepted 1 January 2013

Academic Editor: Wei Jia

Copyright © 2013 Gabriella Hegyi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. Szasz, “Physical background and technical realization of hyperthermia,” in Locoregional Radiofrequency-Perfusional- and Wholebody-Hyperthermia in Cancer Treatment: New Clinical Aspects, G. F. Baronzio and E. D. Hager, Eds., pp. 27–59, Springer Science and Eurekah.com, 2006. View at Google Scholar
  2. M. Israël and L. Schwartz, “The metabolic advantage of tumor cells,” Molecular Cancer, vol. 10, article 70, 2011. View at Google Scholar
  3. A. Szentgyorgyi, Electronic Biology and Cancer, Marcel Dekker, New York, NY, USA, 1998.
  4. B. B. Singh, “Hyperthermia—a new dimension in cancer treatment,” Indian Journal of Biochemistry and Biophysics, vol. 27, no. 4, pp. 195–201, 1990. View at Google Scholar · View at Scopus
  5. F. Westermark, “Uber die Behandlung des ulcerirenden Cervix carcinoma mittels Knonstanter Warme,” Zentralblatt für Gynäkologie, pp. 1335–1339, 1898. View at Google Scholar
  6. H. R. Moyer and K. A. Delman, “The role of hyperthermia in optimizing tumor response to regional therapy,” International Journal of Hyperthermia, vol. 24, no. 3, pp. 251–261, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. C. T. Lee, T. Mace, and E. A. Repasky, “Hypoxia-driven immunosuppression: a new reason to use thermal therapy in the treatment of cancer?” International Journal of Hyperthermia, vol. 26, no. 3, pp. 232–246, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. E. Jones, D. Thrall, M. W. Dewhirst, and Z. Vujaskovic, “Prospective thermal dosimetry: the key to hyperthermia's future,” International Journal of Hyperthermia, vol. 22, no. 3, pp. 247–253, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. E. R. Lee, “Electromagnetic superficial heating technology,” in Thermoradiotherapy and Thermochemotherapy, M. H. Seegenschmiedt, P. Fessenden, and C. C. Vernon, Eds., pp. 193–217, Springer, Berlin, Germany, 1995. View at Google Scholar
  10. P. Wust, M. Seebass, J. Nadobny, and R. Felix, “Electromagnetic deep heating technology,” in Thermoradiotherapy and Thermochemotherapy, M. H. Seegenschmiedt, P. Fessenden, and C. C. Vernon, Eds., pp. 219–251, Springer, Berlin, Germany, 1995. View at Google Scholar
  11. R. B. Roemer, “Engineering aspects of hyperthermia therapy,” Annual Review of Biomedical Engineering, vol. 1, pp. 347–376, 1999. View at Google Scholar
  12. B. Hildebrandt, P. Wust, O. Ahlers et al., “The cellular and molecular basis of hyperthermia,” Critical Reviews in Oncology/Hematology, vol. 43, no. 1, pp. 33–56, 2002. View at Publisher · View at Google Scholar · View at Scopus
  13. D. S. Coffey, R. H. Getzenberg, and T. L. Deweese, “Hyperthermic biology and cancer therapies: a hypothesis for the “Lance Armstrong effect”,” Journal of the American Medical Association, vol. 296, no. 4, pp. 445–448, 2006. View at Publisher · View at Google Scholar · View at Scopus
  14. J. L. Roti, “Cellular responses to hyperthermia (40–46°C): cell killing and molecular events,” International Journal of Hyperthermia, vol. 24, no. 1, pp. 3–15, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. K. Iwata, A. Shakil, W. J. Hur, C. M. Makepeace, R. J. Griffin, and C. W. Song, “Tumour pO2 can be increased markedly by mild hyperthermia,” British Journal of Cancer, vol. 74, supplement, pp. S217–S221, 1996. View at Google Scholar · View at Scopus
  16. C. A. Vidair and W. C. Dewey, “Two distinct modes of hyperthermic cell death,” Radiation Research, vol. 116, no. 1, pp. 157–171, 1988. View at Google Scholar · View at Scopus
  17. B. Gyldenhof, M. R. Horsman, and J. Overgaard, “Hyperthermia-induced changes in the vascularity and histopathology of a murine tumour and its surrounding normal tissue,” in Hyperthermic Oncology, C. Franconi, G. Arcangeli, and R. Cavaliere, Eds., vol. 2, pp. 780–782, Tor Vergata, Rome, Italy, 1996. View at Google Scholar
  18. M. R. Horsman and J. Overgaard, “Can mild hyperthermia improve tumour oxygenation?” International Journal of Hyperthermia, vol. 13, no. 2, pp. 141–147, 1997. View at Google Scholar · View at Scopus
  19. C. W. Song, M. S. Patten, L. M. Chelstrom, J. G. Rhee, and S. H. Levitt, “Effect of multiple heatings on the blood flow in RIF-1 tumours, skin and muscle of C3H mice,” International Journal of Hyperthermia, vol. 3, no. 6, pp. 535–545, 1987. View at Google Scholar · View at Scopus
  20. P. Vaupel, F. Kallinowski, and P. Okunieff, “Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review,” Cancer Research, vol. 49, no. 23, pp. 6449–6465, 1989. View at Google Scholar · View at Scopus
  21. P. W. Vaupel, “Effects of physiological parameters on tissue response to hyperthermia: new experimental facts and their relevance to clinical problems,” in Hyperthermia Oncology, E. W. Gerner and T. C. Cetas, Eds., pp. 17–23, Tucson Arizona Board of Regents, Tucson, Ariz, USA, 19921993. View at Google Scholar
  22. H. H. Kampinga, J. R. Dynlacht, and E. Dikomey, “Mechanism of radiosensitization by hyperthermia (43°C) as derived from studies with DNA repair defective mutant cell lines,” International Journal of Hyperthermia, vol. 20, no. 2, pp. 131–139, 2004. View at Publisher · View at Google Scholar · View at Scopus
  23. A. Laszlo, “The effects of hyperthermia on mammalian cell structure and function,” Cell Proliferation, vol. 25, no. 2, pp. 59–87, 1992. View at Google Scholar · View at Scopus
  24. K. C. Kregel, “Invited review: heat shock proteins: modifying factors in physiological stress responses and acquired thermotolerance,” Journal of Applied Physiology, vol. 92, no. 5, pp. 2177–2186, 2002. View at Google Scholar · View at Scopus
  25. R. A. Coss, W. C. Dewey, and J. R. Bamburg, “Effects of hyperthermia on dividing Chinese hamster ovary cells and on microtubules in vitro,” Cancer Research, vol. 42, no. 3, pp. 1059–1071, 1982. View at Google Scholar · View at Scopus
  26. A. Westra and W. C. Dewey, “Variation in sensitivity to heat shock during the cell-cycle of Chinese hamster cells in vitro,” International Journal of Radiation Biology & Related Studies in Physics, Chemistry & Medicine, vol. 19, pp. 467–477, 1971. View at Google Scholar
  27. D. Stehelin, H. E. Varmus, J. M. Bishop, and P. K. Vogt, “DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA,” Nature, vol. 260, no. 5547, pp. 170–173, 1976. View at Google Scholar · View at Scopus
  28. P. W. Vaupel and D. K. Kelleher, “Pathophysiological and vascular characteristics of tumours and their importance for hyperthermia: heterogeneity is the key issue,” International Journal of Hyperthermia, vol. 26, no. 3, pp. 211–223, 2010. View at Publisher · View at Google Scholar · View at Scopus
  29. K. Newell and I. Tannock, “Regulation of intracellular pH and viability of tumor cells,” Funktionsanalyse Biolog Systeme, vol. 13, pp. 219–234, 1991. View at Google Scholar
  30. M. Stubbs, P. M. J. McSheehy, J. R. Griffiths, and C. L. Bashford, “Causes and consequences of tumour acidity and implications for treatment,” Molecular Medicine Today, vol. 6, no. 1, pp. 15–19, 2000. View at Publisher · View at Google Scholar · View at Scopus
  31. P. Vaupel and D. K. Kelleher, “Metabolic status and reaction to heat of normal and tumor tissue,” in Thermoradiotherapy and Thermochemotherapy, M. H. Seegenschmiedt, P. Fessenden, and C. C. Vernon, Eds., vol. 1, pp. 157–176, Springer, New York, NY, USA, 1995. View at Google Scholar
  32. W. C. Dewey, “Arrhenius relationships from the molecule and cell to the clinic,” International Journal of Hyperthermia, vol. 10, no. 4, pp. 457–483, 1994. View at Google Scholar · View at Scopus
  33. J. R. Lepock, H. E. Frey, and K. P. Ritchie, “Protein denaturation in intact hepatocytes and isolated cellular organelles during heat shock,” Journal of Cell Biology, vol. 122, no. 6, pp. 1267–1276, 1993. View at Google Scholar · View at Scopus
  34. R. I. Morimoto, “Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators,” Genes and Development, vol. 12, no. 24, pp. 3788–3796, 1998. View at Google Scholar · View at Scopus
  35. H. Kai, M. Ann Suico, S. Morino et al., “A novel combination of mild electrical stimulation and hyperthermia: general concepts and applications,” International Journal of Hyperthermia, vol. 25, no. 8, pp. 655–660, 2009. View at Publisher · View at Google Scholar · View at Scopus
  36. S. Lindquist, “The heat-shock response,” Annual Review of Biochemistry, vol. 55, pp. 1151–1191, 1986. View at Google Scholar · View at Scopus
  37. T. Torigoe, Y. Tamura, and N. Sato, “Heat shock proteins and immunity: application of hyperthermia for immunomodulation,” International Journal of Hyperthermia, vol. 25, no. 8, pp. 610–616, 2009. View at Publisher · View at Google Scholar · View at Scopus
  38. P. K. Srivastava, A. B. DeLeo, and L. J. Old, “Tumor rejection antigens of chemically induced sarcomas of inbred mice,” Proceedings of the National Academy of Sciences of the United States of America, vol. 83, no. 10, pp. 3407–3411, 1986. View at Google Scholar · View at Scopus
  39. A. Szasz, N. Szasz, and O. Szasz, Oncothermia—Principles and Practices, Springer, 2010.
  40. G. Andocs, H. Renner, L. Balogh, L. Fonyad, C. Jakab, and A. Szasz, “Strong synergy of heat and modulated electromagnetic field in tumor cell killing,” Radiology and Oncology, vol. 185, no. 2, pp. 120–126, 2009. View at Publisher · View at Google Scholar · View at Scopus
  41. S. Camazine, J. L. Deneubourg, N. R. Franks et al., Self-Organization in Biological Systems. Princeton Studies in Complexity, Princeton University Press, Princeton, NJ, USA, 2003.
  42. E. D. Kirson, Z. Gurvich, R. Schneiderman et al., “Disruption of cancer cell replication by alternating electric fields,” Cancer Research, vol. 64, no. 9, pp. 3288–3295, 2004. View at Publisher · View at Google Scholar · View at Scopus
  43. A. Szasz, G. Vincze, O. Szasz, and N. Szasz, “An energy analysis of extracellular hyperthermia,” Electromagnetic Biology and Medicine, vol. 22, no. 2-3, pp. 103–115, 2003. View at Publisher · View at Google Scholar · View at Scopus
  44. G. Vincze, N. Szasz, and A. Szasz, “On the thermal noise limit of cellular membranes,” Bioelectromagnetics, vol. 26, no. 1, pp. 28–35, 2005. View at Publisher · View at Google Scholar · View at Scopus
  45. C. D. McCaig, A. M. Rajnicek, B. Song, and M. Zhao, “Controlling cell behavior electrically: current views and future potential,” Physiological Reviews, vol. 85, no. 3, pp. 943–978, 2005. View at Publisher · View at Google Scholar · View at Scopus
  46. L. D. Johns, “Nonthermal effects of therapeutic ultrasound: the frequency resonance hypothesis,” Journal of Athletic Training, vol. 37, no. 3, pp. 293–299, 2002. View at Google Scholar · View at Scopus
  47. O. Warburg, Oxygen, The Creator of Differentiation, Biochemical Energetics, Academic Press, New York, NY, USA, 1966, O. Warburg. The Prime Cause and Prevention of Cancer, Revised lecture at the meeting of the Nobel-Laureates on June 30, 1966 at Lindau, Lake Constance, Germany.
  48. R. M. Bremnes, R. Veve, F. R. Hirsch, and W. A. Franklin, “The E-cadherin cell-cell adhesion complex and lung cancer invasion, metastasis, and prognosis,” Lung Cancer, vol. 36, no. 2, pp. 115–124, 2002. View at Publisher · View at Google Scholar · View at Scopus
  49. M. E. Van Gijn, F. Snel, J. P. M. Cleutjens, J. F. M. Smits, and W. M. Blankesteijn, “Overexpression of components of the Frizzled-Dishevelled cascade results in apoptotic cell death, mediated by β-catenin,” Experimental Cell Research, vol. 265, no. 1, pp. 46–53, 2001. View at Publisher · View at Google Scholar · View at Scopus
  50. EUROCARE-3, “European Cancer Database,” http://www.eurocare.org/.
  51. “Surveillance, Epidemiology, and End Results (SEER),” National Cancer Institute, http://www.seer.cancer.gov/.
  52. J. Bogovič, F. Douwes, G. Muravjov, and J. Istomin, “Posttreatment histology and microcirculation status of osteogenic sarcoma after a neoadjuvant chemo- and radiotherapy in combination with local electromagnetic hyperthermia,” Onkologie, vol. 24, no. 1, pp. 55–58, 2001. View at Publisher · View at Google Scholar · View at Scopus
  53. A. Dani, A. Varkonyi, T. Magyar, and A. Szasz, “Clinical study for advanced pancreas cancer treated by oncothermia,” Forum Hyperthermia, Forum Medizine, vol. 2, pp. 13–19, 2008. View at Google Scholar
  54. V. D. Ferrari, S. De Ponti, F. Valcamonico et al., “Deep electro-hyperthermia (EHY) with or without thermo-active agents in patients with advanced hepatic cell carcinoma: phase II study,” Journal of Clinical Oncology, vol. 25, 18S, Article ID 15168, 2007. View at Google Scholar
  55. G. Fiorentini, P. Giovanis, S. Rossi et al., “A phase II clinical study on relapsed malignant gliomas treated with electro-hyperthermia,” In Vivo, vol. 20, no. 6 A, pp. 721–724, 2006. View at Google Scholar · View at Scopus
  56. E. D. Hager, H. Dziambor, D. Höhmann, D. Gallenbeck, M. Stephan, and C. Popa, “Deep hyperthermia with radiofrequencies in patients with liver metastases from colorectal cancer,” Anticancer Research, vol. 19, no. 4, pp. 3403–3408, 1999. View at Google Scholar · View at Scopus
  57. H. Sahinbas, D. H. W. Grönemeyer, E. Böcher, and A. Szasz, “Retrospective clinical study of adjuvant electro-hyperthermia treatment for advanced brain-gliomas,” Deutsche Zeitschrift für Onkologie, vol. 39, no. 4, pp. 154–160, 2007. View at Publisher · View at Google Scholar · View at Scopus