Review Article
Evaluation of the Add-On Effect of Chinese Patent Medicine for Patients with Stable or Unstable Angina: A Systematic Review and Meta-Analysis
Table 3
Chinese herbal medicine plus western medicine versus western medicine alone for treating stable angina: meta-analysis results.
| Events | No. of studies | No. of events/total no. | Combined effect | Heterogeneity | CHM | Control | RR (95% CI) | value | value | value | |
| Stable angina | | | | | | | | | Total heart events | 3 | 23/150 | 45/147 | 0.50 (0.33–0.78) | 0.002 | 0.39 | 0.825 | 0.0 | Death | 2 | 2/115 | 6/115 | 0.38 (0.09–1.61) | 0.190 | 0.01 | 0.920 | 0.0 | Myocardial infarction | 7 | 6/324 | 21/315 | 0.32 (0.14–0.72) | 0.006 | 1.34 | 0.970 | 0.0 | Cardiac arrhythmia | 2 | 7/93 | 25/92 | 0.27 (0.13–0.57) | 0.001 | 0.28 | 0.594 | 0.0 | Heart failure | 3 | 6/168 | 16/165 | 0.37 (0.15–0.91) | 0.031 | 0.27 | 0.875 | 0.0 | Angina | 6 | 26/306 | 55/298 | 0.46 (0.30–0.71) | <0.001 | 2.75 | 0.739 | 0.0 | Fatal events | 1 | 1/45 | 2/42 | 0.47 (0.04–4.96) | 0.527 | — | — | — | Sudden cardiac death | 1 | 2/50 | 3/50 | 0.67 (0.12–3.82) | 0.649 | — | — | — | Bleeding | 1 | 1/40 | 1/36 | 0.90 (0.06–13.87) | 0.940 | — | — | — | Stomach discomfort | 1 | 2/55 | 4/55 | 0.50 (0.10–2.62) | 0.653 | — | — | — | Unstable angina | | | | | | | | | Total heart events | 7 | 36/337 | 78/333 | 0.46 (0.32–0.66) | <0.001 | 1.15 | 0.979 | 0.0 | Death | 1 | 0/40 | 2/38 | 0.19 (0.01–3.84) | 0.279 | — | — | — | Myocardial infarction | 19 | 33/775 | 92/741 | 0.37 (0.26–0.54) | <0.001 | 14.32 | 0.708 | 0.0 | Cardiac arrhythmia | 1 | 5/50 | 10/50 | 0.50 (0.18–1.36) | 0.174 | — | — | — | Heart failure | 2 | 5/80 | 12/77 | 0.41 (0.15–1.09) | 0.075 | 0.10 | 0.754 | 0.0 | Angina | 12 | 40/585 | 99/533 | 0.36 (0.26–0.51) | <0.001 | 7.79 | 0.732 | 0.0 | Fatal events | 4 | 0/147 | 4/147 | 0.33 (0.07–1.62) | 0.173 | 0.00 | 1.000 | 0.0 | Sudden cardiac death | 5 | 0/243 | 9/243 | 0.22 (0.06–0.84) | 0.027 | 0.08 | 0.999 | 0.0 | Cardiac surgery | 2 | 2/56 | 7/56 | 0.29 (0.06–1.32) | 0.108 | 0.33 | 0.564 | 0.0 | PCI | 3 | 3/118 | 9/117 | 0.35 (0.11–1.16) | 0.088 | 0.96 | 0.618 | 0.0 | Bleeding | 1 | 1/31 | 11/31 | 0.09 (0.01–0.66) | 0.018 | — | — | — | Stomach discomfort | 2 | 1/63 | 3/63 | 0.67 (0.11–3.90) | 0.653 | 1.49 | 0.222 | 32.8 | Stable angina or unstable angina | | | | | | | | | Total heart events | 1 | 3/39 | 7/39 | 0.43 (0.12–1.54) | 0.194 | — | — | — | Death | 2 | 6/173 | 11/202 | 0.58 (0.23–1.48) | 0.256 | 0.32 | 0.570 | 0.0 | Myocardial infarction | 4 | 10/320 | 31/348 | 0.34 (0.17–0.68) | 0.002 | 0.46 | 0.984 | 0.0 | Cardiac arrhythmia | 1 | 2/30 | 4/30 | 0.50 (0.10–2.53) | 0.402 | — | — | — | Heart failure | 2 | 12/110 | 26/109 | 0.46 (0.24–0.86) | 0.015 | 0.21 | 0.646 | 0.0 | Angina | 4 | 25/210 | 54/208 | 0.46 (0.30–0.70) | <0.001 | 0.70 | 0.874 | 0.0 | Fatal events | 2 | 4/110 | 9/109 | 0.44 (0.14–1.39) | 0.161 | 0.01 | 0.903 | 0.0 | Sudden cardiac death | 1 | 1/61 | 3/60 | 0.33 (0.04–3.06) | 0.328 | — | — | — | Cardiac operation | 1 | 8/80 | 16/79 | 0.49 (0.22–1.09) | 0.080 | — | — | — | Bleeding | 1 | 1/40 | 1/36 | 0.90 (0.06–13.87) | 0.940 | — | — | — | Stomach discomfort | 3 | 8/130 | 2/129 | 2.99 (0.83–10.73) | 0.094 | 1.04 | 0.594 | 0.0 |
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CHM: chinese herbal medicine; RR: risk ratio; CI: confidence interval; PCI: percutaneous transluminal coronary intervention.
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