Inhibition of Helicobacter pylori CagA-Induced Pathogenesis by Methylantcinate B from Antrodia camphorata
Figure 6
Structural comparisons and modeling simulations for cholesterol and MAB binding to CagA. (a) Chemical structures of cholesterol and triterpenoid MAB. (b) The overall structure of CagA C-terminal domain colored in green and cholesterol binding protein (PDB code: 3IW1) colored in cyan. (c) The model of CagA C-terminal region with cholesterol (stick, colored in yellow). (d) The model of CagA C-terminal domain with MAB (stick, colored in magenta). The numbers of amino acids shown in CagA were directly contacted with the cholesterol (c) or MAB (d) binding sites.