Table 7: Recent studies on application of propolis in medicine.

Application in medicine
Geographic origin of propolisActivity attributedTest performedReferences

Brazil (southern)Anti-HIV activityIn vitro (H9 Lymphocytes)[9]
Brazil Anticancer activityIn vivo—mice (pulmonary tumors) [85]
BrazilAnticancer activityIn vitro (human tumor cell lines)[86]
Brazil (group 3 and group 12)Suppression of dioxinIn vitro [87]
ChileAntioxidant and anticancerIn vitro  
(KB cells—human mouth epidermoid carcinoma cells;
Caco-2 cells—human colon adenocarcinoma cells)
BrazilAnticancer activityIn vitro and in vivo (retinal damage)[89]
Brazil (group 3, group 12, and bud resins of botanical origin)Anticancer activityIn vitro (human prostate epithelial cells)[90]
BrazilAntiinfluenza virus activityIn vivo-mice (influenza virus)[91]
JordanianAntibacterialIn vitro [92]
TunisiaAnticancer activityIn vitro (cancer cell lines—HT29, A549, Hep-2, raw264.7, and Vero)[93]
Brazil (group 12 and artepellin C)ImmunosuppressantIn vitro (CD4 T cell)[94]
PortugalAnticancer activityIn vitro (human renal cancer)[95]
Israel (Kibbutz Yad Mordecai and CAPE)Anticancer activityIn vitro (human T-cell lines)[96]
BrazilAnticancer activityIn vitro (human breast cancer MCF-7 cells)[97]
Brazil (group 12 and group 13)Anticancer activityIn vitro (human cell lins of leukemia)[98]
CAPE (derived from honeybee hive propolis)Anticancer activityIn vitro (human prostate cancer cells)[99]
BrazilAnticancer activityIn vivo—mice (skin carcinogenesis)[100]
PolandAnticancer activityIn vitro (U87MG human glioblastoma)[101]