Rhodiola rosea Impairs Acquisition and Expression of Conditioned Place Preference Induced by Cocaine
Figure 1
Effects of RHO on cocaine-induced hyperactivity. Mice ( per group) were placed in the actimeter for a 30-min adaptation period (0–30 min). Afterwards, two groups received IG vehicle (Veh-sal and Coc), two groups received IG RHO 15 mg/kg (RHO15 + Coc, RHO15), two groups RHO 20 mg/kg (RHO20 + Coc, RHO20), and two groups RHO 25 mg/kg (RHO25 + Coc, RHO25), and their motor activity was registered over another hour (31–60, 61–90 min). Finally, the first two groups received a IP injection of saline (Veh-Sal) or cocaine 25 mg/kg (Coc), and the groups treated with RHO received an IP injection of cocaine 25 mg/kg (RHO15 + Coc, RHO20 + Coc, and RHO25 + Coc) or saline (RHO 15, RHO 20, and RHO 25), and their motor activity was registered over a further hour (91–120, 121–150 min). (a) represents the motor activity of all groups over the complete time of testing (0–150 min) and shows the time of RHO and cocaine administration in the corresponding groups. (b) represents the data for the last hour of the test (after cocaine administration to the corresponding groups). Values are means ± SEM. *; **; significant difference with respect to the values of the control (Veh-sal) group at the same time test.
