Rhodiola rosea Impairs Acquisition and Expression of Conditioned Place Preference Induced by Cocaine
Figure 4
Effects of RHO on the priming- and stress-induced reinstatement of cocaine-induced CPP. Six groups of mice (–13 for group) were conditioned with cocaine (Coc 25 mg/kg, IP), underwent daily extinction sessions until the CPP was extinguished, and received the following treatments before the reinstatement test: vehicle, RHO 15, or 20 mg/kg 45 min before 12.5 mg/kg IP cocaine priming (Coc, Coc + RHO15, Coc + RHO20); vehicle, RHO 15, or 20 mg/kg 45 min before social defeat exposure (SD, SD + RHO15, SD + RHO20). Bars represent the time in seconds spent in the drug-paired compartment before conditioning sessions in the pre-C test (white bars), after conditioning sessions in the post-C test (black bars), in the last extinction session (light gray bars), and in the reinstatement test (dark gray bars). **, significant difference in the time spent in the drug-paired compartment in preconditioning versus post-conditioning or reinstatement test.
