Table of Contents Author Guidelines Submit a Manuscript
Erratum

An erratum for this article has been published. To view the erratum, please click here.

Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 701434, 9 pages
http://dx.doi.org/10.1155/2013/701434
Review Article

Pomegranate Extracts in the Management of Men's Urologic Health: Scientific Rationale and Preclinical and Clinical Data

1Department of Urology, Institute of Urologic Oncology, David Geffen School of Medicine at the University of California, 924 Westwood Boulevard, Suite 1050, Los Angeles, CA 90095-7384, USA
2Department of Urology, University Medicine Greifswald, F.-Sauerbruch-Str., 17 489 Greifswald, Germany

Received 4 December 2012; Accepted 27 February 2013

Academic Editor: David Heber

Copyright © 2013 Kroeger N. et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Multiple strands of research provide growing evidence that diet, nutrition, and life style play a role in the development and the course of urological diseases. Numerous micronutrients and polyphenols found in soy, green tea, and many fruits and vegetables have been described to impact diseases including erectile dysfunction, benign prostatic hyperplasia, and prostate cancer. However, oftentimes these reports lack both a scientific rationale and supportive evidence base. The efficacy of pomegranate, on the other hand, in the modulation of central biological processes like inflammation, hypoxia, and oxidative stress that are important in the pathogenesis of urological maladies has been robustly demonstrated in preclinical in vitro and in vivo studies. Moreover, clinical trials have further supported its use in the treatment of several diseases, in particular in the management of prostate cancer. Herein, we critically review the scientific knowledge about the current role and future prospects for the use of pomegranate extracts in the therapy of erectile dysfunction, benign prostatic hyperplasia, and prostate cancer.