Bromelain Inhibits Allergic Sensitization and Murine Asthma via Modulation of Dendritic Cells

Figure 2

Bromelain treatment through sensitization abrogates the development of AAD upon OVA aerosol challenge. As compared to PBS treated controls, sBr treatment significantly reduced total BAL WBCs (a) as well as lymphocytes and eosinophils (b). sBr also inhibited influx of BAL CD4⁺ and CD8⁺ T lymphocytes and % of CD11c⁺ cells and mean fluorescent intensity of CD86 and MHCII (c). A representative FACS plot (e) compares the MHCII and CD86 expression on lung DCs (CD11c⁺F480⁻) and MACs (CD11c⁺F480⁺) with those in the spleen (𝑛=8–10 per group).

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