Bromelain Inhibits Allergic Sensitization and Murine Asthma via Modulation of Dendritic Cells

Figure 5

sBr treatment through OVA/alum sensitization reduces DCs in the MLN. Animals were treated with sBr and PBS through the first OVA-alum i.p. Upon sacrifice spleen, and pooled MLN (mesenteric lymph nodes) were processed for analysis via flow cytometry. CD3⁻ CD11c⁺ DCs were reduced in MLNs in sBr-treated animals as compared to PBS-treated controls. Both the percentage of CD44⁺ cells (b) and the mean fluorescent intensity (MFI) of CD44 (c) were significantly reduced in the sBr treatment group as compared to the control PBS group. ^∗𝑃<0.05; 𝑛=5 animals per group.

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