Does Oral Ingestion of Piper sarmentosum Cause Toxicity in Experimental Animals?

Table 2

Table showing changes in the relative organ weight of rats throughout the experimental period.

Relative weight (%)	Control	Piper sarmentosum aqueous extract (mg/kg)
	(normal saline)	50 mg/kg	300 mg/kg	2000 mg/kg
Male
Liver	3.63±0.13	3.60±.0.07	3.51±0.12	3.61±0.13
Left kidney	0.35±0.01	0.36±0.02	0.33±0.01	0.34±0.01
Heart	0.39±0.02	0.36±0.02	0.36±0.01	0.32±0.01
Left lung	0.25±0.01	0.25±0.01	0.23±0.01	0.26±0.01
Spleen	0.19±0.01	0.21±0.01	0.18±0.01	0.18±0.00
Left testis	0.49±0.02	0.51±0.03	0.48±0.02	0.53±0.01
Female
Liver	3.44±0.07	3.42±0.05	3.34±0.14	3.64±0.13
Left kidney	0.34±0.01	0.34±0.02	0.35±0.01	0.34±0.01
Heart	0.37±0.02	0.35±0.01	0.34±0.01	0.37±0.01
Left lung	0.30±0.01	0.28±0.01	0.29±0.02	0.26±0.01
Spleen	0.24±0.02	0.25±0.01	0.25±0.01	0.23±0.01
Left ovary	0.04±0.00	0.03±0.001	0.03±0.001	0.03±0.001

Data were expressed as mean ± SEM. *𝑃 value < 0.05 is significant compared to control group; ^#𝑃 value < 0.05 is significant compared to baseline value; ^β𝑃 value < 0.05 is significant compared to other groups.