Does Oral Ingestion of Piper sarmentosum Cause Toxicity in Experimental Animals?

Table 3

Table showing changes in the haematological profile of rats throughout the experimental period.

			Piper sarmentosum aqueous extract (mg/kg)
	Control		50		300		2000
	Pre	Post	Pre	Post	Pre	Post	Pre	Post
Male
RBC (10^6/μL)	6.7±0.4	7.2±0.3	6.9±0.1	7.4±0.2	6.8±0.3	7.6±0.2	6.1±0.2	7.0±0.3
HB (g/dL)	13.1±0.3	14.0±0.5	14.2±0.2	14.5±0.4	13.4±0.2	14.4±0.2	12.5±0.2^𝛽	13.5±0.6
PCV	42.8±0.9	45.5±1.9	45.3±0.3	46.4±1.6	44.5±0.9	52.3±5.4	40.0±1.8^𝛽	43.2±2.0^#
MCV (fL)	67.7±0.7	63.7±0.6	65.7±1.2	63.0±1.0	66.0±1.9	62.0±1.1	66.7±1.2	61.5±0.6
MCH (pg)	20.5±0.3	19.7±0.3	20.7±0.4	19.6±0.4	20.0±0.5	19.0±0.3	20.5±0.4	19.3±0.2
MCHC (g/dL)	30.5±0.2	30.7±0.2	31.7±0.2	31.2±0.2	30.3±0.4	30.5±0.3	31.1±0.6	31.3±0.3
PLT (×10^9/μL)	1028±53	998±149	956±153	1013±116	1122±82	966±106	760±46	723±162
WBC (×10^3/μL)	15.7±1.3	11.4±1.8	16.0±1.3	19.1±3.7^#	18.3±1.8	15.3±2.4	14.0±1.5	10.8±2.3
Female
RBC (10^6/μL)	6.8±.01	6.5±0.2	6.7±0.3	6.9±0.2	7.2±0.1	7.1±0.2	6.6±0.2	6.9±0.1
HB (g/dL)	14.1±0.2	12.9±0.7	13.3±0.4	13.8±0.3	14.3±0.3	13.8±0.4	12.7±0.4	13.4±0.2
PCV	44.3±0.6	40.4±2.4	42.2±1.8	43.5±0.8	44.7±0.7	42.2±1.2	39.8±1.0	41.7±0.4
MCV (fL)	65.0±0.5	61.4±1.1	63.0±1.0	62.8±0.7	62.0±1.3	59.8±0.6	60.8±1.2^∗	59.8±0.8
MCH (pg)	20.5±0.2	19.8±0.3	19.8±0.4	20.2±0.3	20.0±0.6	19.6±0.2	19.4±0.5	19.3±0.3
MCHC (g/dL)	31.7±0.2	32.2±0.2	31.5±0.2	31.8±0.2	32.0±0.4	32.6±0.4	32.0±0.5	32.3±0.2
PLT (×10^9/μL)	998±68	671±65^∗	773±128	947±55	1086±132	927±60	858±115	842±116
WBC (×10^3/μL)	19.4±2.3	11.8±2.1	16.4±1.1	10.5±2.5	14.4±2.1	13.6±0.80	15.2±3.0	11.7±2.1

Data were expressed as mean ± SEM. *𝑃 value < 0.05 is significant compared to control group; ^#𝑃 value < 0.05 is significant compared to baseline value; ^β𝑃 value < 0.05 is significant compared to other groups.