Does Oral Ingestion of Piper sarmentosum Cause Toxicity in Experimental Animals?

Table 5

Table showing changes in the serum liver biochemical profile of rats throughout the experimental period.

			Piper sarmentosum aqueous extract (mg/kg)
	Control		50		300		2000
	Pre	Post	Pre	Post	Pre	Post	Pre	Post
Male
Total protein (g/L)	63±1.1	64.3±1.3	66.7±0.9	63.3±1.5^#	64.8±1.2	66.2±1.4	65.3±2.3	65.3±1.9
Albumin (g/L)	34.3±0.4	35.3±0.8	34.5±0.4	36.7±0.8	34.2±0.6	35.2±0.7	35.0±0.6	35.2±0.8
Globulin (g/L)	32.0±1.3	29.0±0.9	32.2±1.2	26.5±0.9^𝛽	30.5±0.7	31.0±1.3	30.3±2.1	32.0±0.9
Bilirubin (µmol/L)	1±0	1±0	1±0	1±0	1±0	1±0	1±0	1±0
ALP (iu/L)	531±62	372±44	355±21^∗	438±39	416±31	332±31	473±17	338±13
AST (iu/L)	131±18	108±7	132±20	147±28	111±8	115±9	105±7	139±19
ALT (iu/L)	60±4	67±3	61±2	84±11	56±4	66±2	63±5	67±4
GGT (iu/L)	0	0	0	0	0	0	0	0
Female
Total protein (g/L)	74.3±1.3	71.3±1.0	76.2±2.0	66.7±2.1^#	70.7±1.3	69.7±1.2	71.7±2.3	71.5±2.0
Albumin (g/L)	38.51.0	36.0±0.5	37.3±1.1	36.2±1.6	35.0±0.6	35.2±0.6	36.5±2.0	38.5±1.3
Globulin (g/L)	34.8±1.0	35.3±0.8	38.8±2.2	30.5±0.6	35.2±0.4	34.7±0.8	35.2±1.0	33.0±0.9
Bilirubin (µmol/L)	1±0	1±0	1±0	1±0	1±0	1±0	1±0	1±0
ALP (iu/L)	307±35	291.3±19	301±20	260±23	270±25	265±22	367±46	286±16
AST (iu/L)	171±33	149±9	173±27	135±11	146±9	115±2	129±11	116±9
ALT (iu/L)	61±6	57±3	101±19^∗𝛽	56±3	69±8	58±3	63±4	76±4
GGT (iu/L)	0	0	0	0	0	0	0	0

Data were expressed as mean ± SEM. *𝑃 value < 0.05 is significant compared to control group; ^#𝑃 value < 0.05 is significant compared to baseline value; ^β𝑃 value < 0.05 is significant compared to other groups.