Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 715074, 9 pages
http://dx.doi.org/10.1155/2013/715074
Research Article

Activity-Guided Isolation of Bioactive Constituents with Antinociceptive Activity from Muntingia calabura L. Leaves Using the Formalin Test

1Integrative Pharmacogenomics Institute, Universiti Teknologi MARA, 42300 Puncak Alam, Selangor, Malaysia
2Faculty of Pharmacy, Universiti Teknologi MARA, 42300 Puncak Alam, Selangor, Malaysia
3Faculty of Applied Sciences, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia
4Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia

Received 16 February 2013; Revised 28 September 2013; Accepted 1 October 2013

Academic Editor: Evan Paul Cherniack

Copyright © 2013 Mohd. Izwan Mohamad Yusof et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. F. Morton, “Jamaica cherry,” in Fruits of Warm Climates, J. F. Morton, Ed., pp. 65–69, J.F. Morton, Miami, Fla, USA, 1987. View at Google Scholar
  2. M. Jensen, “Trees commonly cultivated in South East Asia: an illustrated field guide,” in FAO Corporate Document Repository, Craftsman Press, Bangkok, Thailand, 2nd edition, 1999. View at Google Scholar
  3. Z. A. Zakaria, S. Mustapha, M. R. Sulaiman, A. M. Mat Jais, M. N. Somchit, and F. C. Abdullah, “The antinociceptive action of aqueous extract from Muntingia calabura leaves: the role of opioid receptors,” Medical Principles and Practice, vol. 16, no. 2, pp. 130–136, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. E. W. M. Verheij and R. E. Coronel, Plant Resources of South East Asia: Edible Fruits and Nuts, PROSEA, Bogor, Indonesia, 2nd edition, 1992.
  5. N. Kaneda, J. M. Pezzuto, D. D. Soejarto et al., “Plant anticancer agents, XLVIII. New cytotoxic flavonoids from Muntingia calabura roots,” Journal of Natural Products, vol. 54, no. 1, pp. 196–206, 1991. View at Google Scholar · View at Scopus
  6. B.-N. Su, E. J. Parka, J. S. Vigo et al., “Activity-guided isolation of the chemical constituents of Muntingia calabura using a quinone reductase induction assay,” Phytochemistry, vol. 63, no. 3, pp. 335–341, 2003. View at Publisher · View at Google Scholar · View at Scopus
  7. Z. A. Zakaria, M. R. Sulaiman, A. M. M. Jais et al., “The antinociceptive activity of Muntingia calabura aqueous extract and the involvement of L-arginine/nitric oxide/cyclic guanosine monophosphate pathway in its observed activity in mice,” Fundamental and Clinical Pharmacology, vol. 20, no. 4, pp. 365–372, 2006. View at Publisher · View at Google Scholar · View at Scopus
  8. Z. A. Zakaria, N. A. M. Nor Hazalin, S. N. H. M. Zaid et al., “Antinociceptive, anti-inflammatory and antipyretic effects of Muntingia calabura aqueous extract in animal models,” Journal of Natural Medicines, vol. 61, no. 4, pp. 443–448, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. Z. A. Zakaria, M. H. Hassan, M. N. H. Nurul Aqmar et al., “Effects of various nonopioid receptor antagonists on the antinociceptive activity of Muntingia calabura extracts in mice,” Methods and Findings in Experimental and Clinical Pharmacology, vol. 29, no. 8, pp. 515–520, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. Z. A. Zakaria, C. A. Fatimah, A. M. Mat Jais et al., “The in vitro antibacterial activity of Muntingia calabura extracts,” International Journal of Pharmacology, vol. 2, no. 4, pp. 439–442, 2006. View at Publisher · View at Google Scholar · View at Scopus
  11. Z. A. Zakaria, A. M. Mohamed, N. S. M. Jamil et al., “In vitro antiproliferative and antioxidant activities of the extracts of Muntingia calabura leaves,” American Journal of Chinese Medicine, vol. 39, no. 1, pp. 183–200, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. M. H. Mohd. Sani, Z. A. Zakaria, T. Balan, L. K. Teh, and M. Z. Salleh, “Antinociceptive activity of methanol extract of Muntingia calabura leaves and the mechanisms of action involved,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 890361, 10 pages, 2012. View at Publisher · View at Google Scholar
  13. M. Zimmermann, “Ethical guidelines for investigations of experimental pain in conscious animals,” Pain, vol. 16, no. 2, pp. 109–110, 1983. View at Publisher · View at Google Scholar · View at Scopus
  14. OECD (Organization for Economic Cooperation and Development), OECD Guidelines for Testing of Chemicals 423: Acute Oral Toxicity-Acute Toxic Class Method, 1st Adoption, Organization for Economic Cooperation and Development, Paris, France, 1996.
  15. J. H. Rosland, A. Tjolsen, B. Maehle, and K. Hole, “The formalin test in mice: effect of formalin concentration,” Pain, vol. 42, no. 2, pp. 235–242, 1990. View at Publisher · View at Google Scholar · View at Scopus
  16. G. Prinsloo, In vitro production of phytoalexins by Helichrysum kraussii [M.S. thesis], University of Pretoria, Pretoria, South Africa, 2002.
  17. K. Sutthanut, B. Sripanidkulchai, C. Yenjai, and M. Jay, “Simultaneous identification and quantitation of 11 flavonoid constituents in Kaempferia parviflora by gas chromatography,” Journal of Chromatography A, vol. 1143, no. 1-2, pp. 227–233, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. N. A. Ghani, N. Ahmat, N. H. Ismail, I. Zakaria, and N. K. N. A. Zawawi, “Chemical constituents and cytotoxic activity of polyalthia cauliflora var. cauliflora,” Research Journal of Medicinal Plant, vol. 6, no. 1, pp. 74–82, 2012. View at Publisher · View at Google Scholar · View at Scopus
  19. A. B. Malmberg and T. L. Yaksh, “Antinociceptive actions of spinal nonsteroidal anti-inflammatory agents on the formalin test in the rat,” Journal of Pharmacology and Experimental Therapeutics, vol. 263, no. 1, pp. 136–146, 1992. View at Google Scholar · View at Scopus
  20. P. R. Verma, A. A. Joharapurkar, V. A. Chatpalliwar, and A. J. Asnani, “Antinociceptive activity of alcoholic extract of Hemidesmus indicus R.Br. in mice,” Journal of Ethnopharmacology, vol. 102, no. 2, pp. 298–301, 2005. View at Publisher · View at Google Scholar · View at Scopus
  21. S. Hunskaar and K. Hole, “The formalin test in mice: dissociation between inflammatory and non-inflammatory pain,” Pain, vol. 30, no. 1, pp. 103–114, 1987. View at Google Scholar · View at Scopus
  22. L. Tang, Y. Chen, Z. Chen, P. M. Blumberg, A. P. Kozikowski, and Z. J. Wang, “Antinociceptive pharmacology of N-(4-chlorobenzyl)-N′-(4-hydroxy-3- iodo-5-methoxybenzyl) thiourea, a high-affinity competitive antagonist of the transient receptor potential vanilloid 1 receptor,” Journal of Pharmacology and Experimental Therapeutics, vol. 321, no. 2, pp. 791–798, 2007. View at Publisher · View at Google Scholar · View at Scopus
  23. N. N. Rajendran, P. Thirugnanasambandam, S. Viswanathan, S. Parvathavarthini, and S. Ramaswamy, “Antinociceptive pattern of flavone and its mechanism as tested by formalin assay,” Indian Journal of Experimental Biology, vol. 38, no. 2, pp. 182–185, 2000. View at Google Scholar · View at Scopus
  24. J.-J. Chen, R.-W. Lin, C.-Y. Duh, H.-Y. Huang, and I.-S. Chen, “Flavones and cytotoxic constituents from the stem bark of Muntingia calabura,” Journal of the Chinese Chemical Society, vol. 51, no. 3, pp. 665–670, 2004. View at Google Scholar · View at Scopus
  25. J.-J. Chen, H.-H. Lee, C.-Y. Duh, and I.-S. Chen, “Cytotoxic chalcones and flavonoids from the leaves of Muntingia calabura,” Planta Medica, vol. 71, no. 10, pp. 970–973, 2005. View at Publisher · View at Google Scholar · View at Scopus
  26. C.-J. Zheng, W.-Z. Tang, B.-K. Huang et al., “Bioactivity-guided fractionation for analgesic properties and constituents of Vitex negundo L. seeds,” Phytomedicine, vol. 16, no. 6-7, pp. 560–567, 2009. View at Publisher · View at Google Scholar · View at Scopus
  27. A. Tjolsen, O.-G. Berge, S. Hunskaar, J. H. Rosland, and K. Hole, “The formalin test: an evaluation of the method,” Pain, vol. 51, no. 1, pp. 5–17, 1992. View at Publisher · View at Google Scholar · View at Scopus
  28. F. De Campos-Buzzi, J. P. De Campos, P. P. Tonini et al., “Antinociceptive effects of synthetic chalcones obtained from xanthoxyline,” Archiv der Pharmazie, vol. 339, no. 7, pp. 361–365, 2006. View at Publisher · View at Google Scholar · View at Scopus
  29. F. De Campos-Buzzi, P. Padaratz, A. V. Meira, R. Corrêa, R. J. Nunes, and V. Cechinel-Filho, “4′-Acetamidochalcone derivatives as potential antinociceptive agents,” Molecules, vol. 12, no. 4, pp. 896–906, 2007. View at Publisher · View at Google Scholar · View at Scopus
  30. P. Padaratz, M. Fracasso, F. De Campos-Buzzi et al., “Antinociceptive activity of a new benzofuranone derived from a chalcone,” Basic and Clinical Pharmacology and Toxicology, vol. 105, no. 4, pp. 257–261, 2009. View at Publisher · View at Google Scholar · View at Scopus
  31. R. Corrêa, M. A. Pereira, D. Buffon et al., “Antinociceptive properties of chalcones. Structure-activity relationships,” Archiv der Pharmazie, vol. 334, no. 10, pp. 332–334, 2001. View at Google Scholar
  32. T. M. Dawson and S. H. Snyder, “Gases as biological messengers: nitric oxide and carbon monoxide in the brain,” Journal of Neuroscience, vol. 14, no. 9, pp. 5147–5159, 1994. View at Google Scholar · View at Scopus
  33. G. Di Carlo, N. Mascolo, A. A. Izzo, and F. Capasso, “Flavonoids: old and new aspects of a class of natural therapeutic drugs,” Life Sciences, vol. 65, no. 4, pp. 337–353, 1999. View at Publisher · View at Google Scholar · View at Scopus
  34. M. R. Peluso, “Flavonoids attenuate cardiovascular disease, inhibit phosphodiesterase, and modulate lipid homeostasis in adipose tissue and liver,” Experimental Biology and Medicine, vol. 231, no. 8, pp. 1287–1299, 2006. View at Google Scholar · View at Scopus
  35. U. R. Kuppusamy and N. P. Das, “Effects of flavonoids on cyclic AMP phosphodiesterase and lipid mobilization in rat adipocytes,” Biochemical Pharmacology, vol. 44, no. 7, pp. 1307–1315, 1992. View at Publisher · View at Google Scholar · View at Scopus
  36. J. E. Ferrell Jr., P. D. G. Chang Sing, and G. Loew, “Structure/activity studies of flavonoids as inhibitors of cyclic AMP phosphodiesterase and relationship to quantum chemical indices,” Molecular Pharmacology, vol. 16, no. 2, pp. 556–568, 1979. View at Google Scholar · View at Scopus
  37. M. M. Teixeira, R. W. Gristwood, N. Cooper, and P. G. Hellewell, “Phosphodiesterase (PDE)4 inhibitors: anti-inflammatory drugs of the future?” Trends in Pharmacological Sciences, vol. 18, no. 5, pp. 164–170, 1997. View at Publisher · View at Google Scholar · View at Scopus
  38. F. E. McCann, A. C. Palfreeman, M. Andrews et al., “Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis,” Arthritis Research and Therapy, vol. 12, no. 3, article R107, 2010. View at Publisher · View at Google Scholar · View at Scopus
  39. C. S. Freitas, C. H. Baggio, A. C. Dos Santos et al., “Antinociceptive properties of the hydroalcoholic extract, fractions and compounds obtained from the aerial parts of Baccharis illinita DC in Mice,” Basic and Clinical Pharmacology and Toxicology, vol. 104, no. 4, pp. 285–292, 2009. View at Publisher · View at Google Scholar · View at Scopus
  40. G. Schmeda-Hirschmann and E. Yesilada, “Traditional medicine and gastroprotective crude drugs,” Journal of Ethnopharmacology, vol. 100, no. 1-2, pp. 61–66, 2005. View at Publisher · View at Google Scholar · View at Scopus