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Evidence-Based Complementary and Alternative Medicine
Volume 2013 (2013), Article ID 715650, 9 pages
Research Article

Antinociceptive and Anti-Inflammatory Activities of the Ethanolic Extract from Synadenium umbellatum Pax. (Euphorbiaceae) Leaves and Its Fractions

1Faculdade de Farmácia, Universidade Federal de Goiás, Avenida Universitária com 1a Avenida, Quadra 62, 2 Andar, Sala 36, 74605-220 Goiânia, GO, Brazil
2Instituto Nacional de Metrologia, Qualidade e Tecnologia (INMETRO), Avenida Nossa Senhora das Graças, 50 Xerém, Duque de Caxias, 25250-020 Rio de Janeiro, RJ, Brazil
3Instituto de Ciências Biológicas, Universidade Federal de Goiás, Campus II-Samambaia, Saída para Nerópolis (Km 13), Caixa Postal 131, 74001-970 Goiânia, GO, Brazil

Received 1 October 2012; Revised 15 December 2012; Accepted 23 December 2012

Academic Editor: Mohd Roslan Sulaiman

Copyright © 2013 Rodrigo Borges et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Synadenium umbellatum Pax., popularly known in Brazil as “cola-nota,” “avelós,” “cancerola,” and “milagrosa”, is a plant species used in folk medicine for the treatment of inflammation, pain, and several diseases. This study aimed to investigate the antinociceptive and anti-inflammatory activities of the ethanolic extract from Synadenium umbellatum Pax. leaves (EES) and its hexane (HF), chloroform (CF), and methanol/water (MF) fractions using the acetic acid-induced abdominal writhing test, formalin-induced paw licking test, tail flick test, croton oil-induced ear edema test, and carrageenan-induced peritonitis test. EES and MF reduced the number of acetic acid-induced abdominal writhes, while CF and HF did not. EES effect on acetic acid-induced abdominal writhing was reversed with a pretreatment with naloxone. EES reduced licking time in both phases of the formalin-induced paw licking test, but did not prolong the latency in the tail flick test. These results show that EES presented antinociceptive activity, probably involving the opioid system, anti-inflammatory activity in the croton oil-induced ear edema test, and leukocyte migration into the intraperitoneal cavity. MF also presented anti-inflammatory activity in the croton oil-induced ear edema test. In conclusion, EES and MF have antinociceptive activity involving the opioid system and anti-inflammatory activity.