Evidence-Based Complementary and Alternative Medicine

Research Article

Autonomic Nervous System Mediates the Hypotensive Effects of Aqueous and Residual Methanolic Extracts of Syzygium polyanthum (Wight) Walp. var. polyanthum Leaves in Anaesthetized Rats

Table 1

ED₅₀ values of AESP and met-AESP-induced hypotension.


Model of rats	ED₅₀ values for the induced hypotension
	AESP			Met-AESP
	MAP	SBP	DBP	MAP	SBP	DBP

WKY	25.28 ± 2.33	21.80 ± 2.34	26.67 ± 2.34	54.58 ± 2.41	63.83 ± 2.37	72.14 ± 2.43
SHR	32.28 ± 2.53	26.32 ± 2.52	32.97 ± 2.58	33.05 ± 2.34	32.08 ± 2.36	32.25 ± 2.34

ED₅₀ value: mean of dose ± SD that causes 50% maximal reduction of MAP, SBP, and DBP, calculated by GraphPad PRISM version 5.01 software by using nonlinear regression equation, MAP: mean arterial blood pressure, SBP: systolic blood pressure, DBP: diastolic blood pressure, AESP: aqueous extract of S. polyanthum leaves, met-AESP: residual methanolic extract of S. polyanthum leaves, WKY: Wistar-Kyoto rats, SHR: spontaneously hypertensive rats.