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Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 724161, 7 pages
Research Article

Study of the Interference between Plectranthus Species Essential Oils from Brazil and Aminoglycosides

1Programa de Pós-Graduação em Biotecnologia, Rede Nordeste de Biotecnologia, Universidade Estadual do Ceará, Avenida Paranjana 1700, Campus do Itaperi, 60740-000 Fortaleza, CE, Brazil
2Programa de Pós-Graduação em Bioprospecção Molecular, Departamento de Química Biológica, Laboratório de Pesquisa de Produtos Naturais, Universidade Regional do Cariri, Rua Cel. Antônio Luiz 1161, Pimenta, 63105-000 Crato, CE, Brazil
3Programa de Pós-Graduação em Biotecnologia, Rede Nordeste de Biotecnologia, Universidade de Fortaleza, Avenida Washington Soares 1321, Edson Queiroz, 60811-905 Fortaleza, CE, Brazil

Received 10 August 2012; Accepted 7 March 2013

Academic Editor: Andrea Pieroni

Copyright © 2013 Fabíola Fernandes Galvão Rodrigues et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Plectranthus is one of the most representative genera of Lamiaceae family. In this study, the essential oils from Plectranthus amboinicus, Plectranthus ornatus, and Plectranthus barbatus were investigated for their chemical composition and antimicrobial and modulatory activities. The major components found were carvacrol (54.4%—P. amboinicus) and eugenol (22.9%—P. ornatus e 25.1%—P. barbatus). In vitro antimicrobial activity was conducted against Escherichia coli, Proteus vulgaris, Bacillus cereus, Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus aureus (multiresistant) using microdilution method. The results of bioassay showed that all strains were sensitive to the oils, except P. aeruginosa that was resistant to P. amboinicus and P. ornatus. A synergistic effect of all essential oils combined with the aminoglycosides was demonstrated. These results show that P. amboinicus, P. ornatus, and P. barbatus inhibit the growth of pathogenic microorganism, and besides this they present antibiotic modifying activity, providing a new perspective against the problem of bacterial resistance to antibiotics.