In Vitro Antileishmanial Activity of Essential Oil of Vanillosmopsis arborea (Asteraceae) Baker

Table 1

Leishmanicidal and cytotoxic activity of VAEO and its major constituent α-bisabolol.

Compounds	IC50 µg/mL		CC50 µg/mL	SI^aama
	Promastigote	Amastigote intracellular	J774.G8
VAEO	7.35 ± 0.050	12.58 ± 0.068	145 ± 0.023	11.526
α-Bisabolol	4.95 ± 0.054	10.70 ± 0.085	100.4 ± 0.025	9.383
Amphotericin B	3.1 ± 0.048	7.8 ± 0.059	1.688 ± 0.4993	0.216

^aSI_ama (selectivity index) = CC₅₀ macrophage/IC₅₀ amastigote.