Antidiabetic Effect of Oral Borapetol B Compound, Isolated from the Plant Tinospora crispa, by Stimulating Insulin Release

Table 1

The effect of different concentrations of T. crispa C1 at low (3.3 mM) and high (16.7 mM) glucose on insulin secretion from W (𝑛=5) and GK (𝑛=3) rat islets.

Addition to incubation medium		Insulin release (μU/islet/h)
Glucose (mM)	T. crispa C1 (μg/mL)	W islets	GK islets
3.3	None	2.4±0.1	1.2±0.2
	0.1	15.1±2.2^∗∗	4.7±0.3^∗
	1	19.5±4^∗	7.5±0.9^∗
	10	21.9±2^∗∗∗	10.5±1.8^∗
16.7	None	32.5±1.8	13.6±0.6
	0.1	48.8±6^#	20.6±1.1^#
	1	63.1±8.9^#	30.9±3.8^#
	10	164.5±11.3^###	57.3±6.3^#

Data are presented as means ± SEM. W: ^∗𝑃<0.05 versus 3.3 mM glucose; ^∗∗𝑃<0.01 versus 3.3 mM glucose; ^∗∗∗𝑃<0.001 versus 3.3 mM glucose; ^#𝑃<0.05 versus 16.7 mM glucose; ^###𝑃<0.001 versus 16.7 mM glucose GK: ^∗𝑃<0.05 versus 3.3 mM glucose; ^#𝑃<0.05 versus 16.7 mM glucose.