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Evidence-Based Complementary and Alternative Medicine
Volume 2013 (2013), Article ID 728020, 15 pages
http://dx.doi.org/10.1155/2013/728020
Research Article

Inhibition of NADPH Oxidase Mediates Protective Effect of Cardiotonic Pills against Rat Heart Ischemia/Reperfusion Injury

1Tasly Microcirculation Research Center, Peking University Health Science Center, Beijing 100191, China
2Department of Integration of Traditional Chinese and Western Medicine, School of Basic Medical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191, China
3Key Laboratory of Microcirculation, State Administration of Traditional Chinese Medicine, Beijing 100191, China
4Key Laboratory of Stasis and Phlegm, State Administration of Traditional Chinese Medicine, Beijing 100191, China

Received 24 February 2013; Revised 14 May 2013; Accepted 22 May 2013

Academic Editor: Hao Xu

Copyright © 2013 Xiao-Yuan Yang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. American Heart Association, Learn and Live. Know the Facts, Get the Stats, American Heart Association, Dallas, Tex, USA, 2006.
  2. S. K. Powers, Z. Murlasits, M. Wu, and A. N. Kavazis, “Ischemia-reperfusion-induced cardiac injury: a brief review,” Medicine and Science in Sports and Exercise, vol. 39, no. 9, pp. 1529–1536, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. G. Ambrosio, L. C. Becker, G. M. Hutchins, H. F. Weisman, and M. L. Weisfeldt, “Reduction in experimental infarct size by recombinant human superoxide dismutase: insights into the pathophysiology of reperfusion injury,” Circulation, vol. 74, no. 6, pp. 1424–1433, 1986. View at Google Scholar · View at Scopus
  4. K. L. Hamilton, “Antioxidants and cardioprotection,” Medicine and Science in Sports and Exercise, vol. 39, no. 9, pp. 1544–1553, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. P. Pagliaro, F. Moro, F. Tullio, M. Perrelli, and C. Penna, “Cardioprotective pathways during reperfusion: focus on redox signaling and other modalities of cell signaling,” Antioxidants and Redox Signaling, vol. 14, no. 5, pp. 833–850, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. K. A. Webster, “Mitochondrial membrane permeabilization and cell death during myocardial infarction: roles of calcium and reactive oxygen species,” Future Cardiology, vol. 8, no. 6, pp. 863–884, 2012. View at Publisher · View at Google Scholar
  7. L. Xiao, D. R. Pimentel, J. Wang, K. Singh, W. S. Colucci, and D. B. Sawyer, “Role of reactive oxygen species and NAD(P)H oxidase in α1-adrenoceptor signaling in adult rat cardiac myocytes,” The American Journal of Physiology, vol. 282, no. 4, pp. C926–C934, 2002. View at Google Scholar · View at Scopus
  8. K. K. Griendling, C. A. Minieri, J. D. Ollerenshaw, and R. W. Alexander, “Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells,” Circulation Research, vol. 74, no. 6, pp. 1141–1148, 1994. View at Google Scholar · View at Scopus
  9. A. Görlach, R. P. Brandes, K. Nguyen, M. Amidi, F. Dehghani, and R. Busse, “A gp91phox containing NADPH oxidase selectively expressed in endothelial cells is a major source of oxygen radical generation in the arterial wall,” Circulation Research, vol. 87, no. 1, pp. 26–32, 2000. View at Google Scholar · View at Scopus
  10. S. Johar, A. C. Cave, A. Narayanapanicker, D. J. Grieve, and A. M. Shah, “Aldosterone mediates angiotensin II-induced interstitial cardiac fibrosis via a Nox2-containing NADPH oxidase,” FASEB Journal, vol. 20, no. 9, pp. 1546–1548, 2006. View at Publisher · View at Google Scholar · View at Scopus
  11. K. Bedard and K. H. Krause, “The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology,” Physiological Reviews, vol. 87, no. 1, pp. 245–313, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. T. Fukui, M. Yoshiyama, A. Hanatani, T. Omura, J. Yoshikawa, and Y. Abe, “Expression of p22-phox and gp91-phox, essential components of NADPH oxidase, increases after myocardial infarction,” Biochemical and Biophysical Research Communications, vol. 281, no. 5, pp. 1200–1206, 2001. View at Publisher · View at Google Scholar · View at Scopus
  13. P. A. J. Krijnen, C. Meischl, C. E. Hack et al., “Increased Nox2 expression in human cardiomyocytes after acute myocardial infarction,” Journal of Clinical Pathology, vol. 56, no. 3, pp. 194–199, 2003. View at Publisher · View at Google Scholar · View at Scopus
  14. S. P. Loukogeorgakis, M. J. van den Berg, R. Sofat et al., “Role of NADPH oxidase in endothelial ischemia/reperfusion injury in humans,” Circulation, vol. 121, no. 21, pp. 2310–2316, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. Y. H. Looi, D. J. Grieve, A. Siva et al., “Involvement of Nox2 NADPH oxidase in adverse cardiac remodeling after myocardial infarction,” Hypertension, vol. 51, no. 2, pp. 319–325, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. F. Qin, M. Simeone, and R. Patel, “Inhibition of NADPH oxidase reduces myocardial oxidative stress and apoptosis and improves cardiac function in heart failure after myocardial infarction,” Free Radical Biology and Medicine, vol. 43, no. 2, pp. 271–281, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. N. Zhao, Y. Liu, F. Wang et al., “Cardiotonic pills, a compound Chinese medicine, protects ischemia-reperfusion-induced microcirculatory disturbance and myocardial damage in rats,” The American Journal of Physiology, vol. 298, no. 4, pp. H1166–H1176, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. X. H. Wei, Y. Y. Liu, Q. Li et al., “Treatment with cardiotonic pills after ischemia-reperfusion ameliorates myocardial fibrosis in rats,” Microcirculation, vol. 20, no. 1, pp. 17–29, 2013. View at Publisher · View at Google Scholar
  19. Z. Qiao, J. Ma, and H. Liu, “Evaluation of the antioxidant potential of Salvia miltiorrhiza ethanol extract in a rat model of ischemia-reperfusion injury,” Molecules, vol. 16, no. 12, pp. 10002–10012, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. J. Han, Y. Horie, J. Fan et al., “Potential of 3,4-dihydroxy-phenyl lactic acid for ameliorating ischemia-reperfusion-induced microvascular disturbance in rat mesentery,” The American Journal of Physiology, vol. 296, no. 1, pp. G36–G44, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. G. Zhao, H. Zhang, T. Ye et al., “Characterization of the radical scavenging and antioxidant activities of danshensu and salvianolic acid B,” Food and Chemical Toxicology, vol. 46, no. 1, pp. 73–81, 2008. View at Publisher · View at Google Scholar · View at Scopus
  22. H. Y. Son, H. S. Han, H. W. Jung, and Y. Park, “Panax notoginseng attenuates the infarct volume in rat ischemic brain and the inflammatory response of microglia,” Journal of Pharmacological Sciences, vol. 109, no. 3, pp. 368–379, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. H. Fan, L. Yang, F. Fu et al., “Cardioprotective effects of salvianolic acid a on myocardial ischemia-reperfusion injury in vivo and in vitro,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 508938, 9 pages, 2012. View at Publisher · View at Google Scholar
  24. Y. Liu, J. Yang, K. Sun, C. Wang, J. Han, and F. Liao, “Determination of erythrocyte flow velocity by dynamic grey scale measurement using off-line image analysis,” Clinical Hemorheology and Microcirculation, vol. 43, no. 3, pp. 265–267, 2009. View at Publisher · View at Google Scholar · View at Scopus
  25. J. Vinten-Johansen, “Involvement of neutrophils in the pathogenesis of lethal myocardial reperfusion injury,” Cardiovascular Research, vol. 61, no. 3, pp. 481–497, 2004. View at Publisher · View at Google Scholar · View at Scopus
  26. H. Zhou, J. Liao, J. Aloor et al., “CD11b/CD18 (Mac-1) is a novel surface receptor for extracellular double-stranded RNA to mediate cellular inflammatory responses,” Journal of Immunology, vol. 190, no. 1, pp. 115–125, 2013. View at Publisher · View at Google Scholar
  27. M. L. Entman and C. W. Smith, “Postreperfusion inflammation: a model for reaction to injury in cardiovascular disease,” Cardiovascular Research, vol. 28, no. 9, pp. 1301–1311, 1994. View at Google Scholar · View at Scopus
  28. N. G. Frangogiannis, C. W. Smith, and M. L. Entman, “The inflammatory response in myocardial infarction,” Cardiovascular Research, vol. 53, no. 1, pp. 31–47, 2002. View at Publisher · View at Google Scholar · View at Scopus
  29. A. Rahman, J. Kefer, M. Bando, W. D. Niles, and A. B. Malik, “E-selectin expression in human endothelial cells by TNF-α-induced oxidant generation and NF-κB activation,” The American Journal of Physiology, vol. 275, no. 3, pp. L533–L544, 1998. View at Google Scholar · View at Scopus
  30. X. Y. Ji, B. K. Tan, and Y. Z. Zhu, “Salvia miltiorrhiza and ischemic diseases,” Acta Pharmacologica Sinica, vol. 21, no. 12, pp. 1089–1094, 2000. View at Google Scholar · View at Scopus
  31. J. Han, J. Fan, Y. Horie et al., “Ameliorating effects of compounds derived from Salvia miltiorrhiza root extract on microcirculatory disturbance and target organ injury by ischemia and reperfusion,” Pharmacology and Therapeutics, vol. 117, no. 2, pp. 280–295, 2008. View at Publisher · View at Google Scholar · View at Scopus
  32. A. Kunwar and K. I. Priyadarsini, “Free radicals, oxidative stress and importance of antioxidants in human health,” Journal of Medical and Allied Sciences, vol. 1, no. 2, pp. 53–60, 2011. View at Google Scholar
  33. B. B. Mathew, A. Tiwari, and S. K. Jatawa, “Free radicals and antioxidants: a review,” Journal of Pharmacy Research, vol. 4, no. 12, pp. 4340–4343, 2011. View at Google Scholar
  34. R. Kohen and A. Nyska, “Oxidation of biological systems: oxidative stress phenomena, antioxidants, redox reactions, and methods for their quantification,” Toxicologic Pathology, vol. 30, no. 6, pp. 620–650, 2002. View at Publisher · View at Google Scholar · View at Scopus
  35. GISSI-Prevenzione Investigators, “Dietary supplementation with N-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial,” The Lancet, vol. 354, no. 9177, pp. 447–455, 1999. View at Publisher · View at Google Scholar · View at Scopus
  36. J. M. McCord, “Therapeutic control of free radicals,” Drug Discovery Today, vol. 9, no. 18, pp. 781–782, 2004. View at Publisher · View at Google Scholar · View at Scopus
  37. B. J. Day, “Catalytic antioxidants: a radical approach to new therapeutics,” Drug Discovery Today, vol. 9, no. 13, pp. 557–566, 2004. View at Publisher · View at Google Scholar · View at Scopus
  38. E. Lonn, J. Bosch, S. Yusuf et al., “Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial,” The Journal of the American Medical Association, vol. 293, no. 11, pp. 1338–1347, 2005. View at Publisher · View at Google Scholar · View at Scopus
  39. T. J. Guzik and D. G. Harrison, “Vascular NADPH oxidases as drug targets for novel antioxidant strategies,” Drug Discovery Today, vol. 11, no. 11-12, pp. 524–533, 2006. View at Publisher · View at Google Scholar · View at Scopus
  40. J. S. McNally, M. E. Davis, D. P. Giddens et al., “Role of xanthine oxidoreductase and NAD(P)H oxidase in endothelial superoxide production in response to oscillatory shear stress,” The American Journal of Physiology, vol. 285, no. 6, pp. H2290–H2297, 2003. View at Google Scholar · View at Scopus
  41. U. Landmesser, S. Dikalov, S. R. Price et al., “Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension,” Journal of Clinical Investigation, vol. 111, no. 8, pp. 1201–1209, 2003. View at Publisher · View at Google Scholar · View at Scopus
  42. K. Kim, K. Takeda, R. Sethi et al., “Protection from reoxygenation injury by inhibition of rac1,” Journal of Clinical Investigation, vol. 101, no. 9, pp. 1821–1826, 1998. View at Google Scholar · View at Scopus
  43. S. Frantz, R. P. Brandes, K. Hu et al., “Left ventricular remodeling after myocardial infarction in mice with targeted deletion of the NADPH oxidase subunit gp91PHOX,” Basic Research in Cardiology, vol. 101, no. 2, pp. 127–132, 2006. View at Publisher · View at Google Scholar · View at Scopus
  44. M. R. Hoffmeyer, S. P. Jones, C. R. Ross et al., “Myocardial ischemia/reperfusion injury in NADPH oxidase-deficient mice,” Circulation Research, vol. 87, no. 9, pp. 812–817, 2000. View at Google Scholar · View at Scopus
  45. Y. Ikeda, L. H. Young, R. Scalia, C. R. Ross, and A. M. Lefer, “PR-39, a proline/arginine-rich antimicrobial peptide, exerts cardioprotective effects in myocardial ischemia-reperfusion,” Cardiovascular Research, vol. 49, no. 1, pp. 69–77, 2001. View at Publisher · View at Google Scholar · View at Scopus
  46. F. E. Rey, M. E. Cifuentes, A. Kiarash, M. T. Quinn, and P. J. Pagano, “Novel competitive inhibitor of NAD(P)H oxidase assembly attenuates vascular O2- and systolic blood pressure in mice,” Circulation Research, vol. 89, no. 5, pp. 408–414, 2001. View at Google Scholar · View at Scopus
  47. V. Diatchuk, O. Lotan, V. Koshkin, P. Wikstroem, and E. Pick, “Inhibition of NADPH oxidase activation by 4-(2-aminoethyl)-benzenesulfonyl fluoride and related compounds,” The Journal of Biological Chemistry, vol. 272, no. 20, pp. 13292–13301, 1997. View at Publisher · View at Google Scholar · View at Scopus
  48. J. Stolk, T. J. Hiltermann, J. H. Dijkman, and A. J. Verhoeven, “Characteristics of the inhibition of NADPH oxidase activation in neutrophils by apocynin, a methoxy-substituted catechol,” The American Journal of Respiratory Cell and Molecular Biology, vol. 11, no. 1, pp. 95–102, 1994. View at Google Scholar · View at Scopus
  49. M. Tsai, Y. Lin, and Y. Huang, “Effects of salvianolic acids on oxidative stress and hepatic fibrosis in rats,” Toxicology and Applied Pharmacology, vol. 242, no. 2, pp. 155–164, 2010. View at Publisher · View at Google Scholar · View at Scopus
  50. S. Gao, Z. Liu, H. Li, P. J. Little, P. Liu, and S. Xu, “Cardiovascular actions and therapeutic potential of tanshinone IIA,” Atherosclerosis, vol. 220, no. 1, pp. 3–10, 2012. View at Publisher · View at Google Scholar · View at Scopus
  51. D. Karthik, P. Viswanathan, and C. V. Anuradha, “Administration of rosmarinic acid reduces cardiopathology and blood pressure through inhibition of p22phox NADPH oxidase in fructose-fed hypertensive rats,” Journal of Cardiovascular Pharmacology, vol. 58, no. 5, pp. 514–521, 2011. View at Publisher · View at Google Scholar · View at Scopus
  52. J. A. Holland, R. W. O'Donnell, M. Chang, D. K. Johnson, and L. M. Ziegler, “Endothelial cell oxidant production: effect of NADPH oxidase inhibitors,” Endothelium, vol. 7, no. 2, pp. 109–119, 1999. View at Google Scholar · View at Scopus
  53. X. Xie, H. Liu, M. Yang, C. Zuo, Y. Deng, and J. Fan, “Ginsenoside Rb1, a panoxadiol saponin against oxidative damage and renal interstitial fibrosis in rats with unilateral ureteral obstruction,” Chinese Journal of Integrative Medicine, vol. 15, no. 2, pp. 133–140, 2009. View at Publisher · View at Google Scholar · View at Scopus