A New Herbal Formula, KSG-002, Suppresses Breast Cancer Growth and Metastasis by Targeting NF-κB-Dependent TNFα Production in Macrophages
Figure 1
KSG-002 suppresses xenograft tumor growth and metastasis. (a) MDA-MB-231 cells were injected subcutaneously into nude mice and were orally added with the extract (500 mg/kg/d) indicated. Xenograft tumor volumes at day 34 posttreatment were presented as means ± standard deviations. . Images show tumors xenografted. (b) Body weights were measured three times a week. (c) CD31-positive vessels in tumor cohorts were counted. Bars indicate means ± standard deviations. . Representative images for anti-CD-31 antibody staining. Arrows indicate CD31-positive vessels. (d) Metastatic tumor foci at the lung were counted. Dots and bars indicate individual numbers and means, respectively. Arrows indicate metastatic foci.
