Research Article
Opposite Effects of Single-Dose and Multidose Administration of the Ethanol Extract of Danshen on CYP3A in Healthy Volunteers
Table 1
Pharmacokinetic parameters of midazolam and 1-hydroxymidazolam after the administration of a single dose of 15 mg of midazolam in 12 healthy volunteers before and after single- and multiple-dose coadministration of the ethanol extract of danshen.
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Data are presented as mean ± SD. *P values are given for the differences with respect to control. The data were analyzed using a one-way analysis of variance with post hoc Dunnett’s procedure. |