Table 1: Pharmacokinetic parameters of midazolam and 1-hydroxymidazolam after the administration of a single dose of 15 mg of midazolam in 12 healthy volunteers before and after single- and multiple-dose coadministration of the ethanol extract of danshen.

PK ParameterControlSingle doseP value*Multiple doseP value*

Midazolam
(ng/mL) 0.00 0.00
(h) 0.07 0.68
(ng·h/mL) 0.70 0.00
(ng·h/mL) 0.65 0.00
(h) 0.61 0.00
 CL/F (L/h) 0.18 0.00
1-Hydroxymidazolam
(ng/mL) 0.01 0.18
(h) 0.12 0.74
(ng·h/mL) 0.12 0.00
(h) 0.16 0.00
0.08 0.00

Data are presented as mean ± SD. *P values are given for the differences with respect to control. The data were analyzed using a one-way analysis of variance with post hoc Dunnett’s procedure.