Evidence-Based Complementary and Alternative Medicine / 2013 / Article / Tab 2

Research Article

Relationship between EGF, TGFA, and EGFR Gene Polymorphisms and Traditional Chinese Medicine ZHENG in Gastric Cancer

Table 2

Relationship between EGF gene polymorphisms and the ZHENG of GC.

SNPsGenotypeType of ZHENG (%)
SSDYDSHDQYDQBDLSDHTSPMOBSOther

rs11568943GG37 (60.7)34 (58.6)13 (56.5)31 (64.6)25 (58.1)32 (59.3)17 (42.5)24 (68.6)14 (63.6)15.0020.524
GA21 (34.4)19 (32.8)9 (39.1)14 (29.2)17 (39.5)18 (33.3)23 (57.5)9 (25.7)7 (31.8)
AA3 (4.9)5 (8.6)1 (4.3)3 (6.2)1 (2.3)4 (7.4)0 (0.0)2 (5.7)1 (4.5)
GA/AA24 (39.3)24 (41.4)10 (43.5)17 (35.4)18 (41.9)22 (40.7)23 (57.5)11 (31.4)8 (36.4)6.7910.559
G allele95 (77.9)87 (75.0)35 (76.1)76 (79.2)67 (77.9)82 (75.9)57 (71.3)57 (81.4)35 (79.5)3.1250.926
A allele27 (22.1)29 (25.0)11 (23.9)20 (20.8)19 (22.1)26 (24.1)23 (28.8)13 (18.6)9 (20.5)

rs3733625AA42 (68.9)36 (62.1)17 (73.9)32 (66.7)34 (79.1)40 (74.1)22 (55.0)26 (74.3)18 (81.8)17.1710.375
GA17 (27.9)21 (36.2)6 (26.1)13 (27.1)8 (18.6)12 (22.2)18 (45.0)8 (22.9)3 (13.6)
GG2 (3.3)1 (1.7)0 (0.0)3 (6.2)1 (2.3)2 (3.7)0 (0.0)1 (2.9)1 (4.5)
GA/GG19 (31.1)22 (37.9)6 (26.1)16 (33.3)9 (20.9)14 (25.9)18 (45.0)9 (25.7)4 (18.2)10.2330.249
A allele101 (82.8)93 (80.2)40 (87.0)77 (80.2)76 (88.4)92 (85.2)62 (77.5)60 (85.7)39 (88.6)6.9460.542
G allele21 (17.2)23 (19.8)6 (13.0)19 (19.8)10 (11.6)16 (14.8)18 (22.5)10 (14.3)5 (11.4)

rs2302135AA31 (50.8)29 (50.9)9 (39.1)23 (47.9)22 (51.2)27 (50.0)21 (52.5)17 (48.6)14 (63.6)5.2180.995
GA26 (42.6)25 (43.9)12 (52.2)22 (45.8)18 (41.9)24 (44.4)18 (45.0)15 (42.9)6 (27.3)
GG4 (6.6)3 (5.3)2 (8.7)3 (6.2)3 (7.0)3 (5.6)1 (2.5)3 (8.6)2 (9.1)
GA/GG30 (49.2)28 (49.1)14 (60.9)25 (52.1)21 (48.8)27 (50.0)19 (47.5)18 (51.4)8 (36.4)2.9690.936
A allele88 (72.1)83 (72.8)30 (65.2)68 (70.8)62 (72.1)78 (72.2)60 (75.0)49 (70.0)34 (77.3)2.260.972
G allele34 (27.9)31 (27.2)16 (34.8)28 (29.2)24 (27.9)30 (27.8)20 (25.0)21 (30.0)10 (22.7)

rs2237051AA24 (39.3)21 (36.2)12 (52.2)19 (39.6)17 (39.5)22 (40.7)19 (47.5)19 (54.3)9 (40.9)15.0400.522
GA29 (47.5)33 (56.9)9 (39.1)26 (54.2)25 (58.1)30 (55.6)18 (45.0)14 (40.0)9 (40.9)
GG8 (13.1)4 (6.9)2 (8.7)3 (6.2)1 (2.3)2 (3.7)3 (7.5)2 (5.7)4 (18.2)
GA/GG37 (60.7)37 (63.8)11 (47.8)29 (60.4)26 (60.5)32 (59.3)21 (52.5)16 (45.7)13 (59.1)4.8750.771
A allele77 (63.1)75 (64.7)33 (71.7)64 (66.7)59 (68.6)74 (68.5)56 (70.0)52 (74.3)27 (61.4)4.4310.816
G allele45 (36.9)41 (35.3)13 (28.3)32 (33.3)27 (31.4)34 (31.5)24 (30.0)18 (25.7)17 (38.6)

rs11568849AA57 (93.4)57 (98.3)21 (95.5)48 (100.0)42 (100.0)51 (94.4)38 (97.4)35 (100.0)21 (95.5)8.7440.364
CA4 (6.6)1 (1.7)1 (4.5)0 (0.0)0 (0.0)3 (5.6)1 (2.6)0 (0.0)1 (4.5)
A allele118 (96.7)115 (99.1)43 (97.7)96 (100.0)84 (100.0)105 (97.2)77 (98.7)70 (100.0)43 (97.7)8.6160.376
C allele4 (3.3)1 (0.9)1 (2.3)0 (0.0)0 (0.0)3 (2.8)1 (1.3)0 (0.0)1 (2.3)

rs3756261AA40 (65.6)36 (62.1)13 (56.5)32 (66.7)28 (65.1)33 (61.1)18 (45.0)21 (61.8)15 (68.2)13.1200.664
GA17 (27.9)17 (29.3)9 (39.1)13 (27.1)14 (32.6)18 (33.3)21 (52.5)12 (35.3)7 (31.8)
GG4 (6.6)5 (8.6)1 (4.3)3 (6.2)1 (2.3)3 (5.6)1 (2.5)1 (2.9)0 (0.0)
GA/GG21 (34.4)22 (37.9)10 (43.5)16 (33.3)15 (34.9)21 (38.9)22 (55.0)13 (38.2)7 (31.8)6.4790.594
A allele97 (79.5)89 (76.7)35 (76.1)77 (80.2)70 (81.4)84 (77.8)57 (71.3)54 (79.4)37 (84.1)4.3770.822
G allele25 (20.5)27 (23.3)11 (23.9)19 (19.8)16 (18.6)24 (22.2)23 (28.8)14 (20.6)7 (15.9)

rs4444903GG27 (44.3)22 (38.6)13 (59.1)20 (45.5)21 (50.0)24 (44.4)20 (50.0)21 (61.8)9 (42.9)14.5180.560
GA27 (44.3)31 (54.4)7 (31.8)19 (43.2)19 (45.2)24 (44.4)19 (47.5)12 (35.3)8 (38.1)
AA7 (11.5)4 (7.0)2 (9.1)5 (11.4)2 (4.8)6 (11.1)1 (2.5)1 (2.9)4 (19.0)
GA/AA34 (55.7)35 (61.4)9 (40.9)24 (54.5)21 (50.0)30 (55.6)20 (50.0)13 (38.2)12 (57.1)6.6820.571
G allele81 (66.4)75 (65.8)33 (75.0)59 (67.0)61 (72.6)72 (66.7)59 (73.8)54 (79.4)26 (61.9)7.9110.442
A allele41 (33.6)39 (34.2)11 (25.0)29 (33.0)23 (27.4)36 (33.3)21 (26.3)14 (20.6)16 (38.1)

rs11569017AA39 (67.2)34 (60.7)13 (61.9)28 (70.0)25 (59.5)34 (64.2)15 (39.5)22 (62.9)15 (68.2)16.1370.443
TA17 (29.3)19 (33.9)8 (38.1)9 (22.5)16 (38.1)16 (30.2)21 (55.3)12 (34.3)5 (22.7)
TT2 (3.4)3 (5.4)0 (0.0)3 (7.5)1 (2.4)3 (5.7)2 (5.3)1 (2.9)2 (9.1)
TA/TT19 (32.8)22 (39.3)8 (38.1)12 (30.0)17 (40.5)19 (35.8)23 (60.5)13 (37.1)7 (31.8)10.5110.231
A allele95 (81.9)87 (77.7)34 (81.0)65 (81.3)66 (78.6)84 (79.2)51 (67.1)56 (80.0)35 (79.5)7.3480.500
T allele21 (18.1)25 (22.3)8 (19.0)15 (18.8)18 (21.4)22 (20.8)25 (32.9)14 (20.0)9 (20.5)

rs11568835GG43 (72.9)49 (84.5)13 (65.0)30 (71.4)27 (65.9)39 (75.0)31 (77.5)22 (66.7)15 (71.4)15.0050.524
GA15 (25.4)7 (12.1)7 (35.0)12 (28.6)12 (29.3)12 (23.1)7 (17.5)11 (33.3)6 (28.6)
AA1 (1.7)2 (3.4)0 (0.0)0 (0.0)2 (4.9)1 (1.9)2 (5.0)0 (0.0)0 (0.0)
GA/AA16 (27.1)9 (15.5)7 (35.0)12 (28.6)14 (34.1)13 (25.0)9 (22.5)11 (33.3)6 (28.6)6.8940.548
G allele101 (85.6)105 (90.5)33 (82.5)72 (85.7)66 (80.5)90 (86.5)69 (86.3)55 (83.3)36 (85.7)4.7170.787
A allele17 (14.4)11 (9.5)7 (17.5)12 (14.3)16 (19.5)14 (13.5)11 (13.8)11 (16.7)6 (14.3)

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