Research Article
Relationship between EGF, TGFA, and EGFR Gene Polymorphisms and Traditional Chinese Medicine ZHENG in Gastric Cancer
Table 2
Relationship between EGF gene polymorphisms and the ZHENG of GC.
| | SNPs | Genotype | Type of ZHENG (%) | | | | SSD | YDSH | DQY | DQB | DLS | DHT | SPM | OBS | Other |
| | rs11568943 | GG | 37 (60.7) | 34 (58.6) | 13 (56.5) | 31 (64.6) | 25 (58.1) | 32 (59.3) | 17 (42.5) | 24 (68.6) | 14 (63.6) | 15.002 | 0.524 | | GA | 21 (34.4) | 19 (32.8) | 9 (39.1) | 14 (29.2) | 17 (39.5) | 18 (33.3) | 23 (57.5) | 9 (25.7) | 7 (31.8) | — | — | | AA | 3 (4.9) | 5 (8.6) | 1 (4.3) | 3 (6.2) | 1 (2.3) | 4 (7.4) | 0 (0.0) | 2 (5.7) | 1 (4.5) | — | — | | GA/AA | 24 (39.3) | 24 (41.4) | 10 (43.5) | 17 (35.4) | 18 (41.9) | 22 (40.7) | 23 (57.5) | 11 (31.4) | 8 (36.4) | 6.791 | 0.559 | | G allele | 95 (77.9) | 87 (75.0) | 35 (76.1) | 76 (79.2) | 67 (77.9) | 82 (75.9) | 57 (71.3) | 57 (81.4) | 35 (79.5) | 3.125 | 0.926 | | A allele | 27 (22.1) | 29 (25.0) | 11 (23.9) | 20 (20.8) | 19 (22.1) | 26 (24.1) | 23 (28.8) | 13 (18.6) | 9 (20.5) | — | — |
| | rs3733625 | AA | 42 (68.9) | 36 (62.1) | 17 (73.9) | 32 (66.7) | 34 (79.1) | 40 (74.1) | 22 (55.0) | 26 (74.3) | 18 (81.8) | 17.171 | 0.375 | | GA | 17 (27.9) | 21 (36.2) | 6 (26.1) | 13 (27.1) | 8 (18.6) | 12 (22.2) | 18 (45.0) | 8 (22.9) | 3 (13.6) | — | — | | GG | 2 (3.3) | 1 (1.7) | 0 (0.0) | 3 (6.2) | 1 (2.3) | 2 (3.7) | 0 (0.0) | 1 (2.9) | 1 (4.5) | — | — | | GA/GG | 19 (31.1) | 22 (37.9) | 6 (26.1) | 16 (33.3) | 9 (20.9) | 14 (25.9) | 18 (45.0) | 9 (25.7) | 4 (18.2) | 10.233 | 0.249 | | A allele | 101 (82.8) | 93 (80.2) | 40 (87.0) | 77 (80.2) | 76 (88.4) | 92 (85.2) | 62 (77.5) | 60 (85.7) | 39 (88.6) | 6.946 | 0.542 | | G allele | 21 (17.2) | 23 (19.8) | 6 (13.0) | 19 (19.8) | 10 (11.6) | 16 (14.8) | 18 (22.5) | 10 (14.3) | 5 (11.4) | — | — |
| | rs2302135 | AA | 31 (50.8) | 29 (50.9) | 9 (39.1) | 23 (47.9) | 22 (51.2) | 27 (50.0) | 21 (52.5) | 17 (48.6) | 14 (63.6) | 5.218 | 0.995 | | GA | 26 (42.6) | 25 (43.9) | 12 (52.2) | 22 (45.8) | 18 (41.9) | 24 (44.4) | 18 (45.0) | 15 (42.9) | 6 (27.3) | — | — | | GG | 4 (6.6) | 3 (5.3) | 2 (8.7) | 3 (6.2) | 3 (7.0) | 3 (5.6) | 1 (2.5) | 3 (8.6) | 2 (9.1) | — | — | | GA/GG | 30 (49.2) | 28 (49.1) | 14 (60.9) | 25 (52.1) | 21 (48.8) | 27 (50.0) | 19 (47.5) | 18 (51.4) | 8 (36.4) | 2.969 | 0.936 | | A allele | 88 (72.1) | 83 (72.8) | 30 (65.2) | 68 (70.8) | 62 (72.1) | 78 (72.2) | 60 (75.0) | 49 (70.0) | 34 (77.3) | 2.26 | 0.972 | | G allele | 34 (27.9) | 31 (27.2) | 16 (34.8) | 28 (29.2) | 24 (27.9) | 30 (27.8) | 20 (25.0) | 21 (30.0) | 10 (22.7) | — | — |
| | rs2237051 | AA | 24 (39.3) | 21 (36.2) | 12 (52.2) | 19 (39.6) | 17 (39.5) | 22 (40.7) | 19 (47.5) | 19 (54.3) | 9 (40.9) | 15.040 | 0.522 | | GA | 29 (47.5) | 33 (56.9) | 9 (39.1) | 26 (54.2) | 25 (58.1) | 30 (55.6) | 18 (45.0) | 14 (40.0) | 9 (40.9) | — | — | | GG | 8 (13.1) | 4 (6.9) | 2 (8.7) | 3 (6.2) | 1 (2.3) | 2 (3.7) | 3 (7.5) | 2 (5.7) | 4 (18.2) | — | — | | GA/GG | 37 (60.7) | 37 (63.8) | 11 (47.8) | 29 (60.4) | 26 (60.5) | 32 (59.3) | 21 (52.5) | 16 (45.7) | 13 (59.1) | 4.875 | 0.771 | | A allele | 77 (63.1) | 75 (64.7) | 33 (71.7) | 64 (66.7) | 59 (68.6) | 74 (68.5) | 56 (70.0) | 52 (74.3) | 27 (61.4) | 4.431 | 0.816 | | G allele | 45 (36.9) | 41 (35.3) | 13 (28.3) | 32 (33.3) | 27 (31.4) | 34 (31.5) | 24 (30.0) | 18 (25.7) | 17 (38.6) | — | — |
| | rs11568849 | AA | 57 (93.4) | 57 (98.3) | 21 (95.5) | 48 (100.0) | 42 (100.0) | 51 (94.4) | 38 (97.4) | 35 (100.0) | 21 (95.5) | 8.744 | 0.364 | | CA | 4 (6.6) | 1 (1.7) | 1 (4.5) | 0 (0.0) | 0 (0.0) | 3 (5.6) | 1 (2.6) | 0 (0.0) | 1 (4.5) | — | — | | A allele | 118 (96.7) | 115 (99.1) | 43 (97.7) | 96 (100.0) | 84 (100.0) | 105 (97.2) | 77 (98.7) | 70 (100.0) | 43 (97.7) | 8.616 | 0.376 | | C allele | 4 (3.3) | 1 (0.9) | 1 (2.3) | 0 (0.0) | 0 (0.0) | 3 (2.8) | 1 (1.3) | 0 (0.0) | 1 (2.3) | — | — |
| | rs3756261 | AA | 40 (65.6) | 36 (62.1) | 13 (56.5) | 32 (66.7) | 28 (65.1) | 33 (61.1) | 18 (45.0) | 21 (61.8) | 15 (68.2) | 13.120 | 0.664 | | GA | 17 (27.9) | 17 (29.3) | 9 (39.1) | 13 (27.1) | 14 (32.6) | 18 (33.3) | 21 (52.5) | 12 (35.3) | 7 (31.8) | — | — | | GG | 4 (6.6) | 5 (8.6) | 1 (4.3) | 3 (6.2) | 1 (2.3) | 3 (5.6) | 1 (2.5) | 1 (2.9) | 0 (0.0) | — | — | | GA/GG | 21 (34.4) | 22 (37.9) | 10 (43.5) | 16 (33.3) | 15 (34.9) | 21 (38.9) | 22 (55.0) | 13 (38.2) | 7 (31.8) | 6.479 | 0.594 | | A allele | 97 (79.5) | 89 (76.7) | 35 (76.1) | 77 (80.2) | 70 (81.4) | 84 (77.8) | 57 (71.3) | 54 (79.4) | 37 (84.1) | 4.377 | 0.822 | | G allele | 25 (20.5) | 27 (23.3) | 11 (23.9) | 19 (19.8) | 16 (18.6) | 24 (22.2) | 23 (28.8) | 14 (20.6) | 7 (15.9) | — | — |
| | rs4444903 | GG | 27 (44.3) | 22 (38.6) | 13 (59.1) | 20 (45.5) | 21 (50.0) | 24 (44.4) | 20 (50.0) | 21 (61.8) | 9 (42.9) | 14.518 | 0.560 | | GA | 27 (44.3) | 31 (54.4) | 7 (31.8) | 19 (43.2) | 19 (45.2) | 24 (44.4) | 19 (47.5) | 12 (35.3) | 8 (38.1) | — | — | | AA | 7 (11.5) | 4 (7.0) | 2 (9.1) | 5 (11.4) | 2 (4.8) | 6 (11.1) | 1 (2.5) | 1 (2.9) | 4 (19.0) | — | — | | GA/AA | 34 (55.7) | 35 (61.4) | 9 (40.9) | 24 (54.5) | 21 (50.0) | 30 (55.6) | 20 (50.0) | 13 (38.2) | 12 (57.1) | 6.682 | 0.571 | | G allele | 81 (66.4) | 75 (65.8) | 33 (75.0) | 59 (67.0) | 61 (72.6) | 72 (66.7) | 59 (73.8) | 54 (79.4) | 26 (61.9) | 7.911 | 0.442 | | A allele | 41 (33.6) | 39 (34.2) | 11 (25.0) | 29 (33.0) | 23 (27.4) | 36 (33.3) | 21 (26.3) | 14 (20.6) | 16 (38.1) | — | — |
| | rs11569017 | AA | 39 (67.2) | 34 (60.7) | 13 (61.9) | 28 (70.0) | 25 (59.5) | 34 (64.2) | 15 (39.5) | 22 (62.9) | 15 (68.2) | 16.137 | 0.443 | | TA | 17 (29.3) | 19 (33.9) | 8 (38.1) | 9 (22.5) | 16 (38.1) | 16 (30.2) | 21 (55.3) | 12 (34.3) | 5 (22.7) | — | — | | TT | 2 (3.4) | 3 (5.4) | 0 (0.0) | 3 (7.5) | 1 (2.4) | 3 (5.7) | 2 (5.3) | 1 (2.9) | 2 (9.1) | — | — | | TA/TT | 19 (32.8) | 22 (39.3) | 8 (38.1) | 12 (30.0) | 17 (40.5) | 19 (35.8) | 23 (60.5) | 13 (37.1) | 7 (31.8) | 10.511 | 0.231 | | A allele | 95 (81.9) | 87 (77.7) | 34 (81.0) | 65 (81.3) | 66 (78.6) | 84 (79.2) | 51 (67.1) | 56 (80.0) | 35 (79.5) | 7.348 | 0.500 | | T allele | 21 (18.1) | 25 (22.3) | 8 (19.0) | 15 (18.8) | 18 (21.4) | 22 (20.8) | 25 (32.9) | 14 (20.0) | 9 (20.5) | — | — |
| | rs11568835 | GG | 43 (72.9) | 49 (84.5) | 13 (65.0) | 30 (71.4) | 27 (65.9) | 39 (75.0) | 31 (77.5) | 22 (66.7) | 15 (71.4) | 15.005 | 0.524 | | GA | 15 (25.4) | 7 (12.1) | 7 (35.0) | 12 (28.6) | 12 (29.3) | 12 (23.1) | 7 (17.5) | 11 (33.3) | 6 (28.6) | — | — | | AA | 1 (1.7) | 2 (3.4) | 0 (0.0) | 0 (0.0) | 2 (4.9) | 1 (1.9) | 2 (5.0) | 0 (0.0) | 0 (0.0) | — | — | | GA/AA | 16 (27.1) | 9 (15.5) | 7 (35.0) | 12 (28.6) | 14 (34.1) | 13 (25.0) | 9 (22.5) | 11 (33.3) | 6 (28.6) | 6.894 | 0.548 | | G allele | 101 (85.6) | 105 (90.5) | 33 (82.5) | 72 (85.7) | 66 (80.5) | 90 (86.5) | 69 (86.3) | 55 (83.3) | 36 (85.7) | 4.717 | 0.787 | | A allele | 17 (14.4) | 11 (9.5) | 7 (17.5) | 12 (14.3) | 16 (19.5) | 14 (13.5) | 11 (13.8) | 11 (16.7) | 6 (14.3) | — | — |
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