Table 3: Relationship between TGFA gene polymorphisms and the ZHENG of GC.

SNPsGenotypeType of ZHENG (%)
SSDYDSHDQYDQBDLSDHTSPMOBSOther

rs3771527TT39 (67.2)37 (68.5)15 (71.4)26 (56.5)32 (80.0)37 (69.8)25 (64.1)22 (64.7)16 (76.2)21.0670.176
TA16 (27.6)17 (31.5)4 (19.0)20 (43.5)8 (20.0)13 (24.5)13 (33.3)11 (32.4)3 (14.3)
AA3 (5.2)0 (0.0)2 (9.5)0 (0.0)0 (0.0)3 (5.7)1 (2.6)1 (2.9)2 (9.5)
TA/AA19 (32.8)17 (31.5)6 (28.6)20 (43.5)8 (20.0)16 (30.2)14 (35.9)12 (35.3)5 (23.8)6.7400.565
T allele94 (81.0)91 (84.3)34 (81.0)72 (78.3)72 (90.0)87 (82.1)63 (80.8)55 (80.9)35 (83.3)5.0190.756
A allele22 (19.0)17 (15.7)8 (19.0)20 (21.7)8 (10.0)19 (17.9)15 (19.2)13 (19.1)7 (16.7)

rs538118AA27 (45.8)24 (41.4)13 (56.5)27 (56.2)24 (58.5)27 (50.9)21 (52.5)17 (48.6)9 (40.9)11.9000.751
GA26 (44.1)28 (48.3)6 (26.1)15 (31.2)15 (36.6)23 (43.4)16 (40.0)15 (42.9)12 (54.5)
GG6 (10.2)6 (10.3)4 (17.4)6 (12.5)2 (4.9)3 (5.7)3 (7.5)3 (8.6)1 (4.5)
GA/GG32 (54.2)34 (58.6)10 (43.5)21 (43.8)17 (41.5)26 (49.1)19 (47.5)18 (51.4)13 (59.1)5.3560.719
A allele80 (67.8)76 (65.5)32 (69.6)69 (71.9)63 (76.8)77 (72.6)58 (72.5)49 (70.0)30 (68.2)3.990.858
G allele38 (32.2)40 (34.5)14 (30.4)27 (28.1)19 (23.2)29 (27.4)22 (27.5)21 (30.0)14 (31.8)

rs473698CC28 (45.9)25 (43.1)13 (56.5)27 (56.2)24 (55.8)29 (53.7)20 (50.0)18 (52.9)9 (40.9)6.7330.978
GC27 (44.3)28 (48.3)8 (34.8)16 (33.3)16 (37.2)23 (42.6)17 (42.5)14 (41.2)11 (50.0)
GG6 (9.8)5 (8.6)2 (8.7)5 (10.4)3 (7.0)2 (3.7)3 (7.5)2 (5.9)2 (9.1)
GC/GG33 (54.1)33 (56.9)10 (43.5)21 (43.8)19 (44.2)25 (46.3)20 (50.0)16 (47.1)13 (59.1)4.3540.824
C allele83 (68.0)78 (67.2)34 (73.9)70 (72.9)64 (74.4)81 (75.0)57 (71.3)50 (73.5)29 (65.9)3.7660.878
G allele39 (32.0)38 (32.8)12 (26.1)26 (27.1)22 (25.6)27 (25.0)23 (28.8)18 (26.5)15 (34.1)

rs3732253CC33 (54.1)25 (43.1)10 (43.5)25 (52.1)18 (41.9)19 (35.2)16 (40.0)20 (57.1)11 (50.0)15.4860.489
TC23 (37.7)27 (46.6)8 (34.8)19 (39.6)22 (51.2)31 (57.4)20 (50.0)14 (40.0)8 (36.4)
TT5 (8.2)6 (10.3)5 (21.7)4 (8.3)3 (7.0)4 (7.4)4 (10.0)1 (2.9)3 (13.6)
TC/TT28 (45.9)33 (56.9)13 (56.5)23 (47.9)25 (58.1)35 (64.8)24 (60.0)15 (42.9)11 (50.0)7.8870.445
C allele89 (73.0)77 (66.4)28 (60.9)69 (71.9)58 (67.4)69 (63.9)52 (65.0)54 (77.1)30 (68.2)7.0970.526
T allele33 (27.0)39 (33.6)18 (39.1)27 (28.1)28 (32.6)39 (36.1)28 (35.0)16 (22.9)14 (31.8)

rs11466306GG33 (54.1)22 (37.9)7 (31.8)25 (52.1)17 (40.5)20 (37.0)18 (45.0)20 (57.1)11 (50.0)15.4770.490
GA23 (37.7)30 (51.7)10 (45.5)18 (37.5)22 (52.4)30 (55.6)18 (45.0)13 (37.1)8 (36.4)
AA5 (8.2)6 (10.3)5 (22.7)5 (10.4)3 (7.1)4 (7.4)4 (10.0)2 (5.7)3 (13.6)
GA/AA28 (45.9)36 (62.1)15 (68.2)23 (47.9)25 (59.5)34 (63.0)22 (55.0)15 (42.9)11 (50.0)9.7430.284
G allele89 (73.0)74 (63.8)24 (54.5)68 (70.8)56 (66.7)70 (64.8)54 (67.5)53 (75.7)30 (68.2)8.7860.361
A allele33 (27.0)42 (36.2)20 (45.5)28 (29.2)28 (33.3)38 (35.2)26 (32.5)17 (24.3)14 (31.8)

rs11466285TT48 (80.0)48 (84.2)20 (90.9)39 (81.2)27 (67.5)49 (92.5)28 (70.0)22 (62.9)18 (81.8)31.0120.013
TC12 (20.0)9 (15.8)2 (9.1)9 (18.8)13 (32.5)4 (7.5)12 (30.0)12 (34.3)3 (13.6)
CC0 (0.0)0 (0.0)0 (0.0)0 (0.0)0 (0.0)0 (0.0)0 (0.0)1 (2.9)1 (4.5)
TC/CC12 (20.0)9 (15.8)2 (9.1)9 (18.8)13 (32.5)4 (7.5)12 (30.0)13 (37.1)4 (18.2)19.7160.011
T allele108 (90.0)105 (92.1)42 (95.5)87 (90.6)67 (83.8)102 (96.2)68 (85.0)56 (80.0)39 (88.6)18.860.016
C allele12 (10.0)9 (7.9)2 (4.5)9 (9.4)13 (16.3)4 (3.8)12 (15.0)14 (20.0)5 (11.4)

rs503314GG24 (42.9)20 (36.4)9 (47.4)22 (48.9)21 (53.8)26 (52.0)19 (48.7)16 (47.1)8 (38.1)6.7200.978
GC25 (44.6)28 (50.9)7 (36.8)17 (37.8)15 (38.5)20 (40.0)17 (43.6)15 (44.1)10 (47.6)
CC7 (12.5)7 (12.7)3 (15.8)6 (13.3)3 (7.7)4 (8.0)3 (7.7)3 (8.8)3 (14.3)
GC/CC32 (57.1)35 (63.6)10 (52.6)23 (51.1)18 (46.2)24 (48.0)20 (51.3)18 (52.9)13 (61.9)4.7930.780
G allele73 (65.2)68 (61.8)25 (65.8)61 (67.8)57 (73.1)72 (72.0)55 (70.5)47 (69.1)26 (61.9)4.9850.759
C allele39 (34.8)42 (38.2)13 (34.2)29 (32.2)21 (26.9)28 (28.0)23 (29.5)21 (30.9)16 (38.1)

rs2166975GG31 (54.4)24 (42.1)9 (42.9)23 (51.1)17 (41.5)20 (38.5)16 (39.0)21 (63.6)10 (45.5)13.4790.637
GA21 (36.8)26 (45.6)7 (33.3)17 (37.8)20 (48.8)26 (50.0)19 (46.3)9 (27.3)8 (36.4)
AA5 (8.8)7 (12.3)5 (23.8)5 (11.1)4 (9.8)6 (11.5)6 (14.6)3 (9.1)4 (18.2)
GA/AA26 (45.6)33 (57.9)12 (57.1)22 (48.9)24 (58.5)32 (61.5)25 (61.0)12 (36.4)12 (54.5)8.9590.346
G allele83 (72.8)74 (64.9)25 (59.5)63 (70.0)54 (65.9)66 (63.5)51 (62.2)51 (77.3)28 (63.6)8.2680.408
A allele31 (27.2)40 (35.1)17 (40.5)27 (30.0)28 (34.1)38 (36.5)31 (37.8)15 (22.7)16 (36.4)