Relationship between EGF, TGFA, and EGFR Gene Polymorphisms and Traditional Chinese Medicine ZHENG in Gastric Cancer

Table 5

Parallel comparison of genotype distribution of EGF, TGFA, and EGFR gene SNPs between the arbitrary two types of ZHENG.

Type of ZHENG	𝜒^2  (𝑃)
	YDSH	DQY	DQB	DLS	DHT	SPM	OBS	Other
SSD	10.731 (0.005)^10a; 5.486 (0.019)^10b	10.174 (0.001)^11a	6.618 (0.010)^11a	—	4.495 (0.034)^11a	—	—	—
YDSH	—	11.517 (0.003)^12a; 8.588 (0.014)^13a	—	—	—	—	—	—
DQY	—	—	—	9.502 (0.002)^7a; 6.647 (0.010)^11a	—	—	4.241 (0.039)^7a; 6.247 (0.044)^12a; 6.247 (0.044)^13a	—
DQB	14.410 (0.001)^12a; 8.136 (0.004)^12b; 11.105 (0.004)^13a; 8.136 (0.004)^13b; 8.197 (0.017)^15a; 7.639 (0.006)^15b	—	—	5.371 (0.020)^5a; 5.022 (0.025)^9b; 4.118 (0.042)^11a; 4.128 (0.042)^11b; 8.225 (0.016)^14a; 7.777 (0.005)^14b	4.828 (0.028)^12a	8.616 (0.013)^1a; 4.292 (0.038)^1b; 8.885 (0.012)^4a; 7.341 (0.007)^4b; 3.884 (0.049)^14b	4.586 (0.032)^3b; 8.213 (0.016)^12a; 5.632 (0.018)^12b; 7.693 (0.021)^13a; 5.632 (0.018)^13b	8.850 (0.012)^5a; 6.527 (0.038)^12a; 5.929 (0.015)^12b; 6.332 (0.042)^13a; 5.929 (0.015)^13b; 6.865 (0.032)^15a; 4.624 (0.032)^15b
DLS	—	—	—	—	—	7.319 (0.026)^2a; 5.470 (0.019)^2b	—	—
DHT	—	—	—	9.502 (0.002)^7a	—	8.068 (0.005)^7a	4.159 (0.041)^6b; 12.092 (0.002)^7a; 11.846 (0.001)^7b; 5.124 (0.024)^8b	—
SPM	—	—	—	—	—	—	9.027 (0.011)^1a; 5.120 (0.024)^1b; 4.430 (0.035)^8b	7.523 (0.023)^2a; 4.459 (0.035)^2b; 6.007 (0.050)^4a; 4.593 (0.032)^4b

1rs11568835, ²rs3733625, ³rs4444903, and ⁴rs11569017 are located in the EGF gene; ⁵rs3771527, ⁶rs3732253, ⁷rs11466285, and ⁸rs2166975 are located in the TGFA gene; ⁹rs6965469, ¹⁰rs17337023, ¹¹rs1140475, ¹²rs884225, ¹³rs884904, ¹⁴rs763317, and ¹⁵rs2072454 are located in the EGFR gene. Namely, ²rs3733625, ⁵rs3771527, ⁶rs3732253, ⁷rs11466285, and ¹²rs884225 are located in the 3′ UTR; ⁴rs11569017, ⁸rs2166975, ¹⁰rs17337023, ¹¹rs1140475, and ¹⁵rs2072454 are located in the exon region; ¹⁴rs763317 is located in intron region; ¹rs11568835, ⁹rs6965469, and ¹³rs884904 are located in the 5′ near region; ³rs4444903 is located in the 5′ UTR.
^aComparison of the three genotypes; ^bcomparison of wild genotype and mutant genotype.