Research Article
A Module Analysis Approach to Investigate Molecular Mechanism of TCM Formula: A Trial on Shu-feng-jie-du Formula
Table 5
Literature-verified pathways related to influenza infection corresponding to four pharmacological units.
| Module | Enriched pathways | -value | Rank | Reference |
| 1 | Regulation of G1/S transition (part 2) | | 1 |
[56] | Influence of Ras and Rho proteins on G1/S Transition | | 2 | EGFR signaling pathway | | 3 | [57] | TGF-beta-dependent induction of EMT via MAPK | | 5 | [58] | AKT signaling | | 7 | [59] | Brca1 as a transcription regulator | | 9 | [60] | Histamine H1 receptor signaling in immune response | | 10 | [61] |
| 2 | Estradiol metabolism (human version) | | 5 |
[62] | Estradiol metabolism | | 7 | Estradiol metabolism (rodent version) | | 8 | Benzo[a]pyrene metabolism | | 9 | [63] | PGE2 signaling in immune response | | 10 | [64] |
| 4 | Apoptotic TNF-family pathways | | 1 | [65] | Role of IAP-proteins in apoptosis | | 2 | [66] | FAS signaling cascades | | 4 | [67] | Inhibition of angiogenesis by PEDF | | 8 | [68] | Granzyme B signaling | | 9 | [69] | Ceramides signaling pathway | | 10 | [70] |
| 5 | TGF, WNT, and cytoskeletal remodeling | | 1 | [71] | Chemokines and adhesion | | 2 | [72] | Cytoskeleton remodeling | | 3 | [73] | HMGB1/RAGE signaling pathway | | 5 | [74] | HSP60 and HSP70/TLR signaling pathway | | 9 | [75] | MIF-mediated glucocorticoid regulation | | 10 | [76] |
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The rank is the order of ascending values of enriched pathways corresponding to each primary pharmacological unit.
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