Saikosaponin-d Enhances the Anticancer Potency of TNF- via Overcoming Its Undesirable Response of Activating NF-Kappa B Signalling in Cancer Cells
Figure 5
Inhibitory effect of Ssd on the TNF-α-induced cancer cell invasion. (a) Ssd suppresses the TNF-α-mediated cell invasion in H1299 cells. Images of invasive cells found in the lower layer of ECMatrix chamber were captured by digital camera under microscope with 100X magnification. (b) The number of invasive cells was counted in the lower layer of ECMatrix chamber membrane. *** for comparison between medium control and TNF-α treatment alone and for Ssd treatment compared to TNF-α treatment alone. (c) The absorbance reading at OD 560 nm of the stained invasive cells solute. ** and *** compared to medium control and TNF-α treatment alone, respectively. (d) Cytotoxicity of Ssd on H1299 cells. Results are mean ± SD from three independent experiments.
