Research Article

Baicalein, Ethyl Acetate, and Chloroform Extracts of Scutellaria baicalensis Inhibit the Neuraminidase Activity of Pandemic 2009 H1N1 and Seasonal Influenza A Viruses

Table 1

Inhibitory effects of MeOH, EtOAc, and chloroform extracts of S. baicalensis on NA enzymatic activity.

Extract NA inhibition IC50 values (μg/mL)
Seasonal 2007 H1N1Pandemic 2009 H1N1PR8 H1N1Seasonal 2009 H1N1Seasonal 2009 H3N2

MeOH613.94 ± 5.54>1000>1000875.92 ± 1.01783.31 ± 0.23
EtOAc73.17 ± 1.65388.98 ± 0.93487.40 ± 1.68176.57 ± 0.32306.96 ± 0.40
Chloroform 109.71 ± 3.08562.94 ± 0.78569.20 ± 0.52251.29 ± 2.30427.55 ± 0.59