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Evidence-Based Complementary and Alternative Medicine
Volume 2013 (2013), Article ID 751658, 17 pages
http://dx.doi.org/10.1155/2013/751658
Review Article

Updates on Antiobesity Effect of Garcinia Origin (−)-HCA

1School of Industrial Technology, University Science Malaysia, 11800 Penang, Malaysia
2School of Biomedical Sciences, The University of Nottingham Malaysia Campus, Jalan Broga, 43300 Semenyih, Selangor, Malaysia
3Department of Bioprocess Technology, Faculty of Biotechnology and Biomolecular Sciences, University Putra Malaysia, 43400 Serdang, Selangor, Malaysia
4Institute of Bioscience, University Putra Malaysia, 43300 Serdang, Selangor, Malaysia

Received 15 June 2013; Accepted 7 July 2013

Academic Editor: Vincenzo De Feo

Copyright © 2013 Li Oon Chuah et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Garcinia is a plant under the family of Clusiaceae that is commonly used as a flavouring agent. Various phytochemicals including flavonoids and organic acid have been identified in this plant. Among all types of organic acids, hydroxycitric acid or more specifically (−)-hydroxycitric acid has been identified as a potential supplement for weight management and as antiobesity agent. Various in vivo studies have contributed to the understanding of the anti-obesity effects of Garcinia/hydroxycitric acid via regulation of serotonin level and glucose uptake. Besides, it also helps to enhance fat oxidation while reducing de novo lipogenesis. However, results from clinical studies showed both negative and positive antiobesity effects of Garcinia/hydroxycitric acid. This review was prepared to summarise the update of chemical constituents, significance of in vivo/clinical anti-obesity effects, and the importance of the current market potential of Garcinia/hydroxycitric acid.