Figure 1: Possible multiple mechanisms that contribute to antiobesity effect of Garcinia/HCA. indicated increase or stimulation; indicated reduce or inhibition while ?? indicated that the effect is yet to be confirmed. (A) summary of Serotonin regulation and food intake suppression; (B) summary of reduction of de novo lipogenesis; (C) summary of stimulation on fat oxidation; (D) summary of reduce on glucose intake; (A) and (B) contribute to the weight management effect of Garcinia/HCA while (B) and (C) contribute to antiobesity of Garcinia/HCA.