Table 3: Summary of clinical studies of Garcinia/HCA that have shown significant antiobesity effect.

DurationSubjectTreatmentOutcome References

10 days44 healthy volunteers4 g for the 1st day followed by 3 g until day 10. Not recorded[59]

11 days Normal, groups: placebo, HCA of total 10 sedentary male under high-fat diet 1500 mg HCA daily No significant effects on body weight gain, appetite-related, and plasma parameters but decreased fat deposition
**Comments: suggest that (−)-HCA may reduce net fat deposition from de novo lipogenesis during weight gain

2 weeks BMI 27.5, groups: placebo, HCA of 24 subjects each (12 males, 12 females) 300 mg HCAReduced of energy intake and slight decreased of body weight[61]

4 weeksObese, hypocaloric diet, groups: placebo, 1 capsule, 2 capsule, (50 subjects each group)55 mg G. cambogia + 19 mg chromium + 240 mg chitosan/dayWeight loss associated with lower TC/LDL and higher HDL[62]

8 weeksBMI 25–35, groups: placebo, treatment of 20 each1000 mg HCA/dayReduced of visceral and subcutaneous fat area[63]

8 weeksModerate obese, groups: placebo, HCA-SX, HCA-SX + NBC + GSE of total 60 HCA-SX 4667 mg (60% HCA), 4667 mg HCA-SX + 400  g niacin-bound chromium + 400 mg Gymnema sylvestre extractSignificant ( ) decrease in BMI, food intake, total cholesterol, low-density lipoproteins, triglycerides, and serum leptin levels, increase in high-density lipoprotein levels, and enhanced excretion of urinary fat metabolites (biomarker of fat oxidation, including malondialdehyde, acetaldehyde, formaldehyde, and acetone) in HCA and HCA-NBC-GSE groups[16]

8 weeksBMI 30–50, groups: placebo, 2800 mg HCA; 2800 mg HCA + 400  g chromium of 30 subjects each2800 mg HCA; 2800 mg of HCA-SX + 400  g chromium + 100 mg gymnemic acid/dayDecreased of body weight, BMI, LDL, and TG and increased fat oxidation[64]

8 weeksNormal, group: 35 healthy subjects on diets 1000, 1200, or 1500 kcal1500 mg G. cambogia extract daily Significant reduction of total cholesterol, triacylglycerol, and body weight associated with reduced appetite [65]

8 weeksObese, groups: placebo and treatment of total 50 F3.45 g G. atroviridis Significant reduction of body weight, BMI, body fat, lean body mass, and anthropometric parameters (biceps, subscapular, suprailiac crest skinfold thicknesses, and upper arm circumference) but no change of serum lipid profile[66]

60 daysOver weight to obese, groups: placebo and treatment of total 58285 mg (−)-HCA in Slim339 G. cambogia extract dailySignificant reduced of body weight (4.7%) [67]

12 weeksBMI 27.5–39, groups: placebo and treatment (18 females/2 males each) of total 40300 mg G. cambogia + 1200 mg Phaseolus vulgaris + 1200 mg inulin/daySignificant body weight lost (3.5 kg versus 1.2 kg)[68]

12 weeksBMI ~28, groups: placebo: 47; treatment: 422400 mg G. cambogia/daySignificant body weight lost [69]