Table 4: Summary of clinical studies of Garcinia/HCA that have shown none significant antiobesity effect.

DurationSubjectTreatmentOutcome References

1 dayNormal, groups: placebo, HCA of total 10 cyclists4300 g HCA No significant changes in total fat and carbohydrate oxidation rates [70]

2 weeks Normal-moderately obese, group: placebo, HCA, and HCA + MCT of total 7 males and 14 females 500 mg HCA; 500 mg HCA + 3 g medium chain triacylglycerols (MCT)No significant differences in satiety, daily energy intake and body weight loss within all groups
**Comment: subjects were under negative energy balance conditions (eliminating the possibility of de novo lipogenesis and reservation of glycogen reserves had occurred; thus, the only possible remaining mechanism increased hepatic fatty acid oxidation)
[71]

2 weeks Normal-moderately obese, groups: placebo, HCA, and HCA + MCT of total 11 male 500 mg HCA; 500 mg HCA + 3 g medium chain triacylglycerols (MCT)No significant differences in body weight reduction, EE, appetite ratings, and substrates oxidation (protein, fat, and carbohydrate oxidation) within all groups
**Comment: 2-week intervention is too short
[41]

2 weeks Normal-moderately obese, groups: placebo, HCA of total 10 sedentary males, with or without moderately intense exercise3 g (−)-HCA daily No significant difference in RQ, EE, and blood parameters during rest nor during exercise [42]

8 weeks39 subjects1500 mg G. cambogia + 300  g chromium picolinate/dayNo significant difference in control and placebo [72]

10 weeksOverweight, groups: treatment: 29; placebo: 292 g G. cambogia extract dailyNo clinically significant differences in body composition, plasma lipid profiles, antioxidant enzyme activity, and plasma adipocytokines[73]

12 week Obese, treatment: 5 M, 61 F; placebo: 14 M, 55 FG. cambogia extract: 3000 mg of (50% of HCA);
Diet: 5020 kJ/day (1200 kcal/day)
No significant difference in body weight and fat mass loss [40]

12 weeksObese, groups: treatment: 36 F, 11 M; placebo: 41 F, 10 MBotanical extract (1000 mg HCA daily)No difference between placebo and treatment group but significant change of the body composition improvement index, body free fat mass, weight, BMI, and some other anthropometric measurements in both treatment and placebo groups [74]

12 weeksObese, groups: treatment: 25 F, 7 M; placebo: 21 F, 5 M. 2.4 g G. cambogia (52.4% HCA) + 1.5 g A. konjac (94.9% glucomannan)No significantvariation in body weight/other anthropometric and calorimetric parameters but significant hypercholesterolemic[75]

12 weeksBMI 28, groups: placebo: 23; treatment: 211,667.3 mg of G. cambogia extract/day (1,000 mg HCA/day)No significant effect[76]