Salvianolic Acid B Prevents Arsenic Trioxide-Induced Cardiotoxicity In Vivo and Enhances Its Anticancer Activity In Vitro

Figure 1

Effects of Sal B and ATO on cardiac dysfunction. Mice were treated with saline or ATO with or without Sal B pretreatment. Echocardiography was performed after 2 weeks. (a) Representative M-mode echocardiograms were shown. (b) Changes in ejection fraction (EF), fractional shortening (FS), left ventricular internal diameter at diastole (LVIDd), and left ventricular internal diameter at systole (LVIDs) in the four groups. Values (𝑛=15 per group) are expressed as means ± SD. *𝑃<0.05 versus control; ^#𝑃<0.05 versus ATO-treated mice.

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