Salvianolic Acid B Prevents Arsenic Trioxide-Induced Cardiotoxicity In Vivo and Enhances Its Anticancer Activity In Vitro

Figure 3

Effects of Sal B treatment on protective protein expressions in heart tissue in vivo. Western blotting was performed on harvested ventricular tissue from mice after 2 weeks of treatment with ATO, Sal B, or both. (a) Effects of Sal B on Akt phosphorylation. Quantitative analysis of the ratio of p-Akt to Akt in protein expression was evaluated. (b) Effects of Sal B on Bcl-2 and Bax. Quantitative analysis of the ratio of Bcl-2 to Bax in protein expression was evaluated. Data are representative of three different experiments. *𝑃<0.05 versus control; **𝑃<0.01 versus control; ^#𝑃<0.05 versus ATO-treated mice; ^##𝑃<0.01 versus ATO-treated mice.

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