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Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 759483, 9 pages
Research Article

Salvianolic Acid B Prevents Arsenic Trioxide-Induced Cardiotoxicity In Vivo and Enhances Its Anticancer Activity In Vitro

1Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China
2Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China
3School of Biological Sciences, University of Edinburgh, King’s Buildings, Edinburgh EH9 3JU, UK
4Academy of Chinese Materia Medica, Wenzhou Medical College, Wenzhou 325035, China

Received 22 December 2012; Revised 2 March 2013; Accepted 2 March 2013

Academic Editor: Angelo Antonio Izzo

Copyright © 2013 Min Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

The optimal doses of Sal B and Sal B and ATO combination treatment were determined in our preliminary study (see Supplementary Data 4). In the normal H9c2 cell lines, combination-treated cells had a higher viability than those cells treated with ATO alone (see Supplementary Data 3). These results are also further confirmed by western blot (see Supplementary Data 1). In cancer cells, however, the effects of the combination are precisely the opposite (see Supplementary Data 2).

  1. Supplementary Data