Trans-β-Caryophyllene: An Effective Antileishmanial Compound Found in Commercial Copaiba Oil (Copaifera spp.)

Figure 5

Cytotoxicity of C1, C4 Copaiba oils, and β-caryophyllene (CAR). Murine peritoneal macrophages were cultured with the compounds at 10 μg/mL for 24 h. Cell viability was verified by Trypan blue dye exclusion assay (a) and XTT method for oil C1 (b), C4 (c), and CAR (d). Cytotoxic activity of 0.5% DMSO (vehicle) and 1% azide were also evaluated. Data represents mean ± SEM of three experiments in duplicates. ^∗𝑃<0.05 for C1, C4, and CAR versus control.

(a)

(b)

(c)

(d)