Clitocybe nuda Activates Dendritic Cells and Acts as a DNA Vaccine Adjuvant
WE-CN enhances the therapeutic effects of a HER-2/neu DNA vaccine against MBT-2 tumors in C3H/HeN mice. Ten days after s.c. MBT-2 inoculation, the tumor-bearing mice were vaccinated with the indicated formulas. (a) The tumor volumes were measured at the indicated times. The mean values ±SD from six to seven mice per group are shown. (b) The Kaplan-Meier survival curve for the different groups of mice is shown. The symbol * indicates a statistically significant difference compared with control group (). The symbol ** indicates comparison with the HER-2/neu DNA vaccine alone group (). The data are representative of three independent experiments with similar results.