Research Article

The Extract of Litsea japonica Reduced the Development of Diabetic Nephropathy via the Inhibition of Advanced Glycation End Products Accumulation in db/db Mice

Table 1

Inhibitory effect of LJE on AGE formation and cross-linking in vitro.

AGE formationAGE cross-links with protein

LJE (IC50)21.21 ± 0.43 μg/mL17.34 μg/mL
Aminoguanidine62.40 μg/mL2.92 ± 0.39 mg/mL

Inhibitory activity was expressed as the mean ± SD of triplicate experiments. The IC50 values were calculated from regression lines using six different concentrations in triplicate experiments.