Evaluation of the Effects of Honey on Acute-Phase Deep Burn Wounds

Table 6

The characteristics of each zone on burn wound.

	Types of burns	Zone of coagulation	Zone of stasis	Zone of hyperemia
Jackson [2]	Flame, scald (human)	White color macroscopically; Nonpatent blood vessels; Coagulation tissue	Change from red to white color macroscopically; Loss of blood vessels and necrosis until days 3–7	Turn to red color until day 4 macroscopically; Heal until day 7; Loss of epidermis, normal dermis, and patent blood vessels
Present research; (H&E)	Scald (mice)	White color macroscopically; Nonpatent blood vessels; Coagulation and necrotic tissue	White color macroscopicallyLoss of epidermis around day 2 or 3, covered surface with eosinophilic like material, and formation of clot	Turn to red color around day 2 or 3; Retention of epidermis, normal dermis, and patent blood vessels
Present research; (anti-HMGB1 antibody, day 4, and no treatment)	Scald (mice)	Almost 100% in all parameters	Epidermis: 93.0%; Appendage: 89.3%; Dermis: 94.68%; Blood vessel: 96.2%; Adipose tissue: 98.0%	Epidermis: 86.7%; Appendage: 80.2%; Dermis: 93.5%; Blood vessel: 96.3%; Adipose tissue: 97.5%
Present research; (anti-HMGB1 antibody, unburned skin)	Unburned skin	Epidermis: 50.2%; Appendage: 47.0%; Dermis: 62.8%; Blood vessel: 56.8%; Adipose tissue: 57.2%