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Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 787138, 8 pages
http://dx.doi.org/10.1155/2013/787138
Research Article

Scopoletin Inhibits Rat Aldose Reductase Activity and Cataractogenesis in Galactose-Fed Rats

Korean Medicine Based Herbal Drug Development Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine (KIOM), 1672 Yuseongdaero, Yuseong-gu, Daejeon 305-811, Republic of Korea

Received 15 February 2013; Revised 13 August 2013; Accepted 13 August 2013

Academic Editor: Ravirajsinh Jadeja

Copyright © 2013 Junghyun Kim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. N. Ughade, S. P. Zodpey, and V. A. Khanolkar, “Risk factors for cataract: a case control study,” Indian Journal of Ophthalmology, vol. 46, no. 4, pp. 221–227, 1998. View at Google Scholar · View at Scopus
  2. H. M. Cheng and R. G. Gonzalez, “The effect of high glucose and oxidative stress on lens metabolism, aldose reductase, and senile cataractogenesis,” Metabolism, vol. 35, no. 4, pp. 10–14, 1986. View at Google Scholar · View at Scopus
  3. A. Y. Lee and S. S. Chung, “Contributions of polyol pathway to oxidative stress in diabetic cataract,” FASEB Journal, vol. 13, no. 1, pp. 23–30, 1999. View at Google Scholar · View at Scopus
  4. J. K. Grover, S. Yadav, and V. Vats, “Medicinal plants of India with anti-diabetic potential,” Journal of Ethnopharmacology, vol. 81, no. 1, pp. 81–100, 2002. View at Publisher · View at Google Scholar · View at Scopus
  5. J. Lee, D. S. Jang, N. H. Kim, Y. M. Lee, J. Kim, and J. S. Kim, “Galloyl glucoses from the seeds of Cornus officinalis with inhibitory activity against protein glycation, aldose reductase, and cataractogenesis ex vivo,” Biological and Pharmaceutical Bulletin, vol. 34, no. 3, pp. 443–446, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. D. S. Jang, Y. M. Lee, I. H. Jeong, and J. S. Kim, “Constituents of the flowers of Platycodon grandiflorum with inhibitory activity on advanced glycation end products and rat lens aldose reductase in vitro,” Archives of Pharmacal Research, vol. 33, no. 6, pp. 875–880, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. A. Kato, Y. Higuchi, H. Goto et al., “Inhibitory effects of Zingiber officinale roscoe derived components on aldose reductase activity in vitro and in vivo,” Journal of Agricultural and Food Chemistry, vol. 54, no. 18, pp. 6640–6644, 2006. View at Publisher · View at Google Scholar · View at Scopus
  8. H. Matsuda, H. Cai, M. Kuro, H. Tosa, and M. Inuma, “Study on anti-cataract drugs from natural sources. II. Effects of Buddlejae Flos on in vitro aldose reductase activity,” Biological and Pharmaceutical Bulletin, vol. 18, no. 3, pp. 463–466, 1995. View at Google Scholar · View at Scopus
  9. M. Kubo, H. Matsuda, K. Tokuoka, Y. Kobayashi, S. Ma, and T. Tanaka, “Studies of anti-cataract drugs from natural sources. I. Effects of a methanolic extract and the alkaloidal components from Corydalis tuber on in vitro aldose reductase activity,” Biological and Pharmaceutical Bulletin, vol. 17, no. 3, pp. 458–459, 1994. View at Google Scholar · View at Scopus
  10. M. Miyazawa, H. Kasahara, and H. Kameoka, “Phenolic lignans from flower buds of Magnolia fargesii,” Phytochemistry, vol. 31, no. 10, pp. 3666–3668, 1992. View at Google Scholar · View at Scopus
  11. N.-H. Nam, Y. Kim, Y.-J. You, D.-H. Hong, H.-M. Kim, and B.-Z. Ahn, “Preliminary structure-antiangiogenic activity relationships of 4-senecioyloxymethyl-6,7-dimethoxycoumarin,” Bioorganic and Medicinal Chemistry Letters, vol. 12, no. 17, pp. 2345–2348, 2002. View at Publisher · View at Google Scholar · View at Scopus
  12. S. Lee, K. Sivakumar, W. Shin, F. Xie, and Q. Wang, “Synthesis and anti-angiogenesis activity of coumarin derivatives,” Bioorganic and Medicinal Chemistry Letters, vol. 16, no. 17, pp. 4596–4599, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. P.-D. Moon, B.-H. Lee, H.-J. Jeong et al., “Use of scopoletin to inhibit the production of inflammatory cytokines through inhibition of the IκB/NF-κB signal cascade in the human mast cell line HMC-1,” European Journal of Pharmacology, vol. 555, no. 2-3, pp. 218–225, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. Z. Ding, Y. Dai, and Z. Wang, “Hypouricemic action of scopoletin arising from xanthine oxidase inhibition and uricosuric activity,” Planta Medica, vol. 71, no. 2, pp. 183–185, 2005. View at Publisher · View at Google Scholar · View at Scopus
  15. C.-Y. Shaw, C.-H. Chen, C.-C. Hsu, C.-C. Chen, and Y.-C. Tsai, “Antioxidant properties of scopoletin isolated from Sinomonium acutum,” Phytotherapy Research, vol. 17, no. 7, pp. 823–825, 2003. View at Publisher · View at Google Scholar · View at Scopus
  16. S. Panda and A. Kar, “Evaluation of the antithyroid, antioxidative and antihyperglycemic activity of scopoletin from Aegle marmelos leaves in hyperthyroid rats,” Phytotherapy Research, vol. 20, no. 12, pp. 1103–1105, 2006. View at Publisher · View at Google Scholar · View at Scopus
  17. J. Lee, N. H. Kim, J. W. Nam et al., “Scopoletin from the flower buds of Magnolia fargesii inhibits protein glycation, aldose reductase, and cataractogenesis ex Vivo,” Archives of Pharmacal Research, vol. 33, no. 9, pp. 1317–1323, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. A. C. Woollard, Z. A. Bascal, G. R. Armstrong, and S. P. Wolff, “Abnormal redox status without increased lipid peroxidation in sugar cataract,” Diabetes, vol. 39, no. 11, pp. 1347–1352, 1990. View at Google Scholar · View at Scopus
  19. M. F. Lou and J. E. Dickerson Jr., “Protein-thiol mixed disulfides in human lens,” Experimental Eye Research, vol. 55, no. 6, pp. 889–896, 1992. View at Publisher · View at Google Scholar · View at Scopus
  20. L. B. Ellwein and C. Kupfer, “Strategic issues in preventing cataract blindness in developing countries,” Bulletin of the World Health Organization, vol. 73, no. 5, pp. 681–690, 1995. View at Google Scholar · View at Scopus
  21. J. H. Kinoshita, “Mechanisms initiating cataract formation. Proctor lecture,” Investigative Ophthalmology, vol. 13, no. 10, pp. 713–724, 1974. View at Google Scholar · View at Scopus
  22. M. F. Lou, J. E. Dickerson Jr., R. Garadi, and B. M. York Jr., “Glutathione depletion in the lens of galactosemic and diabetic rats,” Experimental Eye Research, vol. 46, no. 4, pp. 517–530, 1988. View at Google Scholar · View at Scopus
  23. V. N. Reddy, D. Schwass, B. Chakrapani, and C. P. Lim, “Biochemical changes associated with the development and reversal of galactose cataracts,” Experimental Eye Research, vol. 23, no. 5, pp. 483–493, 1976. View at Google Scholar · View at Scopus
  24. I. Miwa, M. Kanbara, H. Wakazono, and J. Okuda, “Analysis of sorbitol, galactitol, and myo-inositol in lens and sciatic nerve by high-performance liquid chromatography,” Analytical Biochemistry, vol. 173, no. 1, pp. 39–44, 1988. View at Google Scholar · View at Scopus
  25. D. Dvornik, N. Simard Duquesne, and M. Krami, “Polyol accumulation in galactosemic and diabetic rats: control by an aldose reductase inhibitor,” Science, vol. 182, no. 4117, pp. 1146–1148, 1973. View at Google Scholar · View at Scopus
  26. S. Lightman, “Does aldose reductase have a role in the development of the ocular complications of diabetes?” Eye, vol. 7, no. 2, pp. 238–241, 1993. View at Google Scholar · View at Scopus
  27. S. K. Gupta, V. K. Selvan, S. S. Agrawal, and R. Saxena, “Advances in pharmacological strategies for the prevention of cataract development,” Indian Journal of Ophthalmology, vol. 57, no. 3, pp. 175–183, 2009. View at Publisher · View at Google Scholar · View at Scopus
  28. D. R. Tomlinson, E. J. Stevens, and L. T. Diemel, “Aldose reductase inhibitors and their potential for the treatment of diabetic complications,” Trends in Pharmacological Sciences, vol. 15, no. 8, pp. 293–297, 1994. View at Publisher · View at Google Scholar · View at Scopus
  29. H. A. Jung, M. D. N. Islam, Y. S. Kwon et al., “Extraction and identification of three major aldose reductase inhibitors from Artemisia montana,” Food and Chemical Toxicology, vol. 49, no. 2, pp. 376–384, 2011. View at Publisher · View at Google Scholar · View at Scopus
  30. Z. Wang, B. Ling, R. Zhang, and Y. Liu, “Docking and molecular dynamics study on the inhibitory activity of coumarins on aldose reductase,” Journal of Physical Chemistry B, vol. 112, no. 32, pp. 10033–10040, 2008. View at Publisher · View at Google Scholar · View at Scopus
  31. S. L. Liu, M. T. Hsieh, and C. H. Liu, “Plasma scopoletin levels after a single dose oral administration in rabbits,” Chinese Pharmaceutical Journal, vol. 52, no. 4, pp. 203–210, 2000. View at Google Scholar · View at Scopus
  32. Y. Xia, Y. Dai, Q. Wang, and H. Liang, “Determination of scopoletin in rat plasma by high performance liquid chromatographic method with UV detection and its application to a pharmacokinetic study,” Journal of Chromatography B, vol. 857, no. 2, pp. 332–336, 2007. View at Publisher · View at Google Scholar · View at Scopus
  33. R. J. Yin, X. F. Xiao, Y. Y. Xu et al., “Research information and review on the leaves of Diospyros kaki L II. Pharmacokinetics of major active compounds of Diospyros kaki L,” Asian Journal of Pharmacogynamics and Pharmacokinetics, vol. 10, no. 4, pp. 271–285, 2010. View at Google Scholar
  34. M. J. Lizak, E. F. Secchi, J. W. Lee et al., “3-FG as substrate for investigating flux through the polyol pathway in dog lens by 19F-NMR spectroscopy,” Investigative Ophthalmology and Visual Science, vol. 39, no. 13, pp. 2688–2695, 1998. View at Google Scholar · View at Scopus
  35. D. J. Heaf and D. J. Galton, “Sorbitol and other polyols in lens, adipose tissue and urine in diabetes mellitus,” Clinica Chimica Acta, vol. 63, no. 1, pp. 41–47, 1975. View at Google Scholar · View at Scopus
  36. S. K. Srivastava and N. H. Ansari, “Prevention of sugar-induced cataractogenesis in rats by butylated hydroxytoluene,” Diabetes, vol. 37, no. 11, pp. 1505–1508, 1988. View at Google Scholar · View at Scopus
  37. S. P. Wolff and M. J. C. Crabbe, “Low apparent aldose reductase activity produced by monosaccharide autoxidation,” Biochemical Journal, vol. 226, no. 3, pp. 625–630, 1985. View at Google Scholar · View at Scopus
  38. P. M. Abreu, S. Matthew, T. González et al., “Isolation and identification of antioxidants from Pedilanthus tithymaloides,” Journal of Natural Medicines, vol. 62, no. 1, pp. 67–70, 2008. View at Publisher · View at Google Scholar · View at Scopus
  39. C. Shaw, C. Chen, C. Hsu, C. Chen, and Y. Tsai, “Antioxidant properties of scopoletin isolated from Sinomonium acutum,” Phytotherapy Research, vol. 17, no. 7, pp. 823–825, 2003. View at Publisher · View at Google Scholar · View at Scopus