1,4-dihydroxy-2-naphthoic Acid Induces Apoptosis in Human Keratinocyte: Potential Application for Psoriasis Treatment

Figure 12

Effect of DHNA and dithranol on IL-1α releasefrom NCTC 2544 cells. NCTC 2544 cells were treated with vehicle (0.2% DMSO), medium only or (a) 20 to 100 μM (4.08 to 20.42 μg/mL) DHNA or (b) 2 to 8 μM (0.45 to 1.81 μg/mL) dithranol for 72 h and then assayed for IL-1α release by the IL-1α ELISA Kit. Three independent experiments with duplicates each time were performed with similar results. Data are expressed as mean ± SEM from one representative experiment and significant difference at ^∗𝑃<0.05, ^∗∗𝑃<0.01, ^∗∗∗𝑃<0.001 when versus vehicle control.

(a)

(b)