1,4-dihydroxy-2-naphthoic Acid Induces Apoptosis in Human Keratinocyte: Potential Application for Psoriasis Treatment

Table 1

Comparison of IC₅₀ of DHNA, dithranol, and EA on the growth of HaCaT, NCTC 2544, Hs-68, and PIG1 cell lines.

Cell line	Incubation; time (h)	IC50 in µM (µg/mL)^1
		DHNA^2	Dithranol	EA^3
HaCaT	48	111.4 (22.75)	24.77 (5.60)	(2.21)
	72	38.94 (7.95)	9.39 (2.12)	(1.49)
NCTC 2544	48	81.37 (16.61)	6.21 (1.41)	(4.51)
	72	46.80 (9.56)	3.81 (0.86)	(2.50)
Hs-68	72	226.3 (46.21)	27.42 (6.20)	(43.95)
PIG1	72	23.98 (4.90)	2.34 (0.53)	(4.80)

1At least five different concentrations of compound/extract were used for the calculation of each value. Three independent experiments done in triplicate were performed with similar results.
²1,4-dihydroxy-2-naphthoic acid.
³Ethyl acetate extract of the root of Rubia cordifolia L.